4-Bromo-2-fluoroaniline

CAS NO.：367-24-8
Empirical Formula: C6H5BrFN
Molecular Weight: 190.01
MDL number: MFCD00010221
EINECS: 206-685-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-08 10:59:09

What is 4-Bromo-2-fluoroaniline?

Chemical properties

solid

The Uses of 4-Bromo-2-fluoroaniline

4-Bromo-2-fluoroaniline can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

The Uses of 4-Bromo-2-fluoroaniline

4-Bromo-2-fluoroaniline was used in synthesis of 4-amino-3-fluorophenyl boronic acid. It was also used in chemical modification and synthesis of boronic acid derivatives for ultraviolet-visible titration.

What are the applications of Application

4-Bromo-2-fluoroaniline is used in the synthesis of 4-amino-3-fluorophenyl boronic acid

Synthesis

Synthesis_367-24-8
To a stirred solution of 4-bromo-2-fluoro-l -nitrobenzene (10 g, 45.5 mmol) in EtOH (50 mL)AVater (20 mL) was added iron (12.7 g, 230 mmol) and NH4C1 (24.3 g, 455 mmol). The reaction mixture was stirred at 90 ??C for 2 h. After 2 h the reaction mixture was filtered over Celite. The filter cake was washed with EtOH (300 mL), and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (S1O2, Petroleum ether/EtOAc=10: l to 5: 1) to afford 4-bromo-2-fluoroaniline.

Properties of 4-Bromo-2-fluoroaniline

Melting point:	40-42 °C
Boiling point:	103-108 °C (13 mmHg)
Density	1.6196 (rough estimate)
refractive index	1.4710 (estimate)
Flash point:	220 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	Crystalline Mass, Powder, Crystals and/or Chunks
pka	2.50±0.10(Predicted)
color	Beige to light brown to brown-gray or gray
BRN	2081089
Stability:	Stable. Incompatible with acid chlorides, acid anhydrides, strong acids, strong oxidizing agents.
InChI	InChI=1S/C6H5BrFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
CAS DataBase Reference	367-24-8(CAS DataBase Reference)
NIST Chemistry Reference	4-Bromo-2-fluoroaniline(367-24-8)

Safety information for 4-Bromo-2-fluoroaniline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.