4-Bromo-1-naphthylamine
Synonym(s):4-Bromo-1-naphthylamine
- CAS NO.:2298-07-9
- Empirical Formula: C10H8BrN
- Molecular Weight: 222.08
- MDL number: MFCD00004023
- EINECS: 218-944-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-09 09:30:41
What is 4-Bromo-1-naphthylamine?
Chemical properties
pale purple fibrous powder
The Uses of 4-Bromo-1-naphthylamine
1-Amino-4-bromonaphthalene is a reagent used in catalytic asymmetric ring opening of meso-epoxides with aromatic amines in water. It can also be used to synthesize of 4-quinolones and quinolone heterocycles.
What are the applications of Application
1-Amino-4-bromonaphthalene is a naphthalene derivative
Synthesis
4-Bromo-1-naphthylamine is synthesised using 1-(acetylamino)-4-bromonaphthalene as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 4-bromo-1-acetamido naphthalene obtained in the first step is dissolved in 100 mL of 95% ethanol, and the mass concentration of 4-bromo-1-acetylaminonaphthalene in the mixed solution is 30%, and the mass concentration is 37% added to the mixed solution. 50mL of concentrated hydrochloric acid, reacted at 80 ° C for 6h, filtered and dried to give 4-bromo-1-naphthylamine.
Properties of 4-Bromo-1-naphthylamine
Melting point: | 102-103 °C(lit.) |
Boiling point: | 338.4±17.0 °C(Predicted) |
Density | 1.563±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
form | powder to crystal |
pka | 2.93±0.10(Predicted) |
color | White to Amber to Dark purple |
InChI | InChI=1S/C10H8BrN/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H,12H2 |
CAS DataBase Reference | 2298-07-9(CAS DataBase Reference) |
Safety information for 4-Bromo-1-naphthylamine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Bromo-1-naphthylamine
InChIKey | LIUKLAQDPKYBCP-UHFFFAOYSA-N |
SMILES | C1(N)=C2C(C=CC=C2)=C(Br)C=C1 |
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