4-Bromo-1-naphthylamine

Synonym(s):4-Bromo-1-naphthylamine

CAS NO.：2298-07-9
Empirical Formula: C10H8BrN
Molecular Weight: 222.08
MDL number: MFCD00004023
EINECS: 218-944-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-09 09:30:41

What is 4-Bromo-1-naphthylamine?

Chemical properties

pale purple fibrous powder

The Uses of 4-Bromo-1-naphthylamine

1-Amino-4-bromonaphthalene is a reagent used in catalytic asymmetric ring opening of meso-epoxides with aromatic amines in water. It can also be used to synthesize of 4-quinolones and quinolone heterocycles.

What are the applications of Application

1-Amino-4-bromonaphthalene is a naphthalene derivative

Synthesis

4-Bromo-1-naphthylamine is synthesised using 1-(acetylamino)-4-bromonaphthalene as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 4-bromo-1-acetamido naphthalene obtained in the first step is dissolved in 100 mL of 95% ethanol, and the mass concentration of 4-bromo-1-acetylaminonaphthalene in the mixed solution is 30%, and the mass concentration is 37% added to the mixed solution. 50mL of concentrated hydrochloric acid, reacted at 80 ° C for 6h, filtered and dried to give 4-bromo-1-naphthylamine.
4-Bromo-1-naphthylamine synthesis

Properties of 4-Bromo-1-naphthylamine

Melting point:	102-103 °C(lit.)
Boiling point:	338.4±17.0 °C(Predicted)
Density	1.563±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	2.93±0.10(Predicted)
color	White to Amber to Dark purple
InChI	InChI=1S/C10H8BrN/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H,12H2
CAS DataBase Reference	2298-07-9(CAS DataBase Reference)

Safety information for 4-Bromo-1-naphthylamine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.