4-Bromo-1-butene

CAS NO.：5162-44-7
Empirical Formula: C4H7Br
Molecular Weight: 135
MDL number: MFCD00000258
EINECS: 225-937-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is 4-Bromo-1-butene?

Chemical properties

colourless liquid

The Uses of 4-Bromo-1-butene

4-Bromo-1-butene is a brominated alkene used as a reagent in organic synthesis.

The Uses of 4-Bromo-1-butene

4-Bromo-1-butene is used in the preparation of 4-(3-butenyloxy)benzoic acid and largazole. It is also used in double alkylation of lactams followed by Grubbs ring-closing metathesis to yield gymnodimine. Further, it serves as a reagent in the preparation of dienehydrazides.

What are the applications of Application

4-Bromo-1-butene is used for preparation of dienehydrazides

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 251, 1984 DOI: 10.1016/S0040-4039(00)99853-8

General Description

Stereoselective epoxidation of 4-bromo-1-butene was carried out with three alkene-utilizing bacteria: Mycobacterium LI, Mycobacterium E3 and Nocardia IP1.

Properties of 4-Bromo-1-butene

Melting point:	-115.07°C (estimate)
Boiling point:	98-100 °C (lit.)
Density	1.33 g/mL at 25 °C (lit.)
refractive index	n20/D 1.462(lit.)
Flash point:	49 °F
storage temp.	Store below +30°C.
solubility	0.76g/l
form	Liquid
color	Clear colorless to light brownish
Specific Gravity	1.330
Water Solubility	Miscible with water, benzene, ether and ethanol.
Sensitive	Light Sensitive
BRN	1098377
Stability:	Stable. Incompatible with strong bases, strong oxidizing agents. Highly flammable. Light sensitive.
CAS DataBase Reference	5162-44-7(CAS DataBase Reference)
NIST Chemistry Reference	1-Butene, 4-bromo-(5162-44-7)
EPA Substance Registry System	1-Butene, 4-bromo- (5162-44-7)

Safety information for 4-Bromo-1-butene

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.