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HomeProduct name list4-Aminothiophenol

4-Aminothiophenol

Synonym(s):4-Aminobenzenethiol;4-Aminophenyl mercaptan;4-Mercaptoaniline

  • CAS NO.:1193-02-8
  • Empirical Formula: C6H7NS
  • Molecular Weight: 125.19
  • MDL number: MFCD00007880
  • EINECS: 214-763-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-15 19:19:13
4-Aminothiophenol Structural

What is 4-Aminothiophenol?

Chemical properties

yellow crystalline low melting mass

The Uses of 4-Aminothiophenol

4-Aminothiophenol (4-ATP) was employed as bifunctional molecule to functionalize gold nanoparticles (NPs) used in surface-enhanced Raman spectroscopy (SERS) detection of thrombin by protein recognition.

The Uses of 4-Aminothiophenol

4-Aminothiophenol is used in the synthesis of pectin-4-aminothiophenol conjugates and it forms self-assembled monolayers (SAMs) in the development of DNA. It is used in the detection of thrombin by protein recognition using surface-enhanced Raman spectroscopy (SERS), which finds applications in silver and gold nano particles. It acts as a linker to thiol (SH) functionalizes multiwalled carbon nanotubes (MWCNTs).

Preparation

synthesis of 4-aminothiophenol: A mixture of 128 g. of p-chloronitrobenzene and a solution of 480 g. of sodium sulfide nonahydrate in 2 l. of water is heated to reflux for 8 hours. The cooled mixture is extracted with ether to remove a small amount of oil, the remaining aqueous solution is saturated with sodium chloride, and 240 g. of glacial acetic acid is added. The precipitated oil is removed by ether extraction, and the resulting ethereal solution is dried over sodium sulfate and distilled to give 70 g. (69%) of 4-aminothiophenol boiling at 143-146°/17 mm. and melting at 43-45°.

General Description

4-Aminothiophenol (p-aminothiophenol, PATP) is an aromatic thiol. The self-assembly of silver and gold nano particles which are interconnected with 4-ATP to form metal-molecule-metal sandwich architecture has been characterized by surface enhanced Raman scattering (SERS) using an off-surface plasmon resonance condition. Chemical transformation of PATP to 4,4-dimercaptoazobenzene (DMAB) has been extensively studied.

Properties of 4-Aminothiophenol

Melting point: 37-42 °C(lit.)
Boiling point: 140-145 °C16 mm Hg(lit.)
Density  1.136 (estimate)
refractive index  1.4606 (estimate)
Flash point: >230 °F
storage temp.  2-8°C
solubility  7.3g/l
form  Crystals, Flakes or Crystalline Mass
pka 8.74±0.10(Predicted)
color  Off-white to brown
Water Solubility  Immiscible with water.
Sensitive  Stench
BRN  906904
CAS DataBase Reference 1193-02-8(CAS DataBase Reference)
NIST Chemistry Reference 4-Aminothiophenol(1193-02-8)
EPA Substance Registry System 4-Aminothiophenol (1193-02-8)

Safety information for 4-Aminothiophenol

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Aminothiophenol

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