4-Aminothiophenol
Synonym(s):4-Aminobenzenethiol;4-Aminophenyl mercaptan;4-Mercaptoaniline
- CAS NO.:1193-02-8
- Empirical Formula: C6H7NS
- Molecular Weight: 125.19
- MDL number: MFCD00007880
- EINECS: 214-763-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4-Aminothiophenol?
Chemical properties
yellow crystalline low melting mass
The Uses of 4-Aminothiophenol
4-Aminothiophenol is used in the synthesis of pectin-4-aminothiophenol conjugates and it forms self-assembled monolayers (SAMs) in the development of DNA. It is used in the detection of thrombin by protein recognition using surface-enhanced Raman spectroscopy (SERS), which finds applications in silver and gold nano particles. It acts as a linker to thiol (SH) functionalizes multiwalled carbon nanotubes (MWCNTs).
The Uses of 4-Aminothiophenol
4-Aminothiophenol (4-ATP) was employed as bifunctional molecule to functionalize gold nanoparticles (NPs) used in surface-enhanced Raman spectroscopy (SERS) detection of thrombin by protein recognition.
Preparation
synthesis of 4-aminothiophenol: A mixture of 128 g. of p-chloronitrobenzene and a solution of 480 g. of sodium sulfide nonahydrate in 2 l. of water is heated to reflux for 8 hours. The cooled mixture is extracted with ether to remove a small amount of oil, the remaining aqueous solution is saturated with sodium chloride, and 240 g. of glacial acetic acid is added. The precipitated oil is removed by ether extraction, and the resulting ethereal solution is dried over sodium sulfate and distilled to give 70 g. (69%) of 4-aminothiophenol boiling at 143-146°/17 mm. and melting at 43-45°.
General Description
4-Aminothiophenol (p-aminothiophenol, PATP) is an aromatic thiol. The self-assembly of silver and gold nano particles which are interconnected with 4-ATP to form metal-molecule-metal sandwich architecture has been characterized by surface enhanced Raman scattering (SERS) using an off-surface plasmon resonance condition. Chemical transformation of PATP to 4,4-dimercaptoazobenzene (DMAB) has been extensively studied.
Properties of 4-Aminothiophenol
Melting point: | 37-42 °C(lit.) |
Boiling point: | 140-145 °C16 mm Hg(lit.) |
Density | 1.136 (estimate) |
refractive index | 1.4606 (estimate) |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | 7.3g/l |
form | Crystals, Flakes or Crystalline Mass |
pka | 8.74±0.10(Predicted) |
color | Off-white to brown |
Water Solubility | Immiscible with water. |
Sensitive | Stench |
BRN | 906904 |
CAS DataBase Reference | 1193-02-8(CAS DataBase Reference) |
NIST Chemistry Reference | 4-Aminothiophenol(1193-02-8) |
EPA Substance Registry System | 4-Aminothiophenol (1193-02-8) |
Safety information for 4-Aminothiophenol
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Aminothiophenol
Abamectin manufacturer
BASR Fine Chemicals Pvt. Ltd.
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