4-Amino-2-chloropyridine
- CAS NO.：14432-12-3
- Empirical Formula: C5H5ClN2
- Molecular Weight: 128.56
- MDL number: MFCD00060089
- EINECS: 238-403-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-13 11:39:26
What is 4-Amino-2-chloropyridine?
The Uses of 4-Amino-2-chloropyridine
4-Amino-2-chloropyridine may be used in the preparation of:
- 3-deazacytosine
- 7-substituted 1-alky-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acids
- 1,6-naphthyridines
Definition
ChEBI: 4-Amino-2-chloropyridine is an aminopyridine.
What are the applications of Application
4-Amino-2-chloropyridine is an aminopyridine derivative with potential herbicidal activity. It is used as a drug and pigment intermediate. It is an additive for plant growth regulators.
General Description
4-Amino-2-chloropyridine is a chloroaminoheterocyclic compound. It readily undergoes Suzuki-Miyaura coupling with phenylboronic acid.
Synthesis
4-Amino-2-chloropyridine is also known as 2-chloro-4-aminopyridine and is synthesised as follows:
(1) Using 2-chloropyridine as raw material and chloroform as solvent, 2-chloropyridine oxide is generated under the action of metachloroperbenzoic acid;
(2) 2-chloropyridine oxide is reacted with concentrated nitric acid and concentrated sulphuric acid CID to generate 2-chloro-4-nitro pyridine nitric oxide;
(3) 2-chloro-4-nitro pyridine nitric oxide is reduced to 2-chloro-4-aminopyridine.
Properties of 4-Amino-2-chloropyridine
| Melting point: | 90-94 °C(lit.) |
| Boiling point: | 153°C 5mm |
| Density | 1.2417 (rough estimate) |
| refractive index | 1.5110 (estimate) |
| Flash point: | 153°C/5mm |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.73±0.30(Predicted) |
| form | Crystalline Powder |
| color | Light yellow |
| Water Solubility | Slightly soluble in water. |
| BRN | 108671 |
| CAS DataBase Reference | 14432-12-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Amino-2-chloropyridine(14432-12-3) |
Safety information for 4-Amino-2-chloropyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Amino-2-chloropyridine
| InChIKey | BLBDTBCGPHPIJK-UHFFFAOYSA-N |
4-Amino-2-chloropyridine manufacturer
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