2-Chloropyridine

CAS NO.：109-09-1
Empirical Formula: C5H4ClN
Molecular Weight: 113.54
MDL number: MFCD00006228
EINECS: 203-646-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:31

What is 2-Chloropyridine?

Chemical properties

Clear colourless to light yellow liquid

The Uses of 2-Chloropyridine

2-Chloropyridine (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during t he decomposition of specific insecticides.

The Uses of 2-Chloropyridine

2- Chloropyridine is used as an intermediate chemical in the production of various pyrithione, for use in cosmetics, personal care products and pharmaceutical products.

Definition

ChEBI: 2-chloropyridine is a monochloropyridine.

Synthesis Reference(s)

Synthetic Communications, 19, p. 897, 1989 DOI: 10.1080/00397918908051009
Synthesis, p. 337, 1990

General Description

A colorless oily liquid. Toxic by ingestion and/or skin absorption. Used to make other chemicals.

Air & Water Reactions

Slightly soluble in water and denser than water.

Hazard

Toxic by ingestion.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by ingestion, inhalation, skin contact, and intraperitoneal routes. Combustible when exposed to heat or flame. Can react with oxidizing materials. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and phosgene.

Purification Methods

Dry 2-chloropyridine with NaOH for several days, then distil it from CaO under reduced pressure. [Beilstein 20/5 V 402.]

Properties of 2-Chloropyridine

Melting point:	-46 °C
Boiling point:	166 °C/714 mmHg (lit.)
Density	1.2 g/mL at 25 °C (lit.)
vapor pressure	1.7 mm Hg ( 20 °C)
refractive index	n20/D 1.532(lit.)
Flash point:	149 °F
storage temp.	Refrigerator
solubility	27g/l
form	Liquid
pka	0.49(at 25℃)
color	Clear colorless to light yellow
PH	6-7 (27g/l, H2O, 20℃)
Water Solubility	27 g/L (20 ºC)
BRN	105788
CAS DataBase Reference	109-09-1(CAS DataBase Reference)
NIST Chemistry Reference	Pyridine, 2-chloro-(109-09-1)
EPA Substance Registry System	2-Chloropyridine (109-09-1)

Safety information for 2-Chloropyridine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection.