(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one
- CAS NO.：63038-10-8
- Empirical Formula: C12H16O2
- Molecular Weight: 192.26
- MDL number: MFCD16660665
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is (3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one?
Description
Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities. It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml. It also reverses increases in protein levels of phosphatase 2A (PP2A) and α-synuclein and reverses decreases in the phosphorylated forms of PP2A and α-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC50 = 54.17 μM) but not non-cancerous human CCD-18Co colon cells (IC50 = 109.11 μM).
Definition
ChEBI: Senkyunolide is a member of 2-benzofurans.
Properties of (3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml |
| form | Liquid |
| color | Colorless to light yellow |
Safety information for (3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one
Computed Descriptors for (3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one
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