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HomeProduct name listAmmothamnine

Ammothamnine

  • CAS NO.:16837-52-8
  • Empirical Formula: C15H24N2O2
  • Molecular Weight: 264.36
  • MDL number: MFCD00210339
  • EINECS: 605-514-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
Ammothamnine Structural

What is Ammothamnine?

Description

An alkaloid from Sophora angustifolia var. flavescens S. and Z., the bas'e crystal_x0002_lizes as the monohydrate having the lower melting point given above. It is dextrorotatory with [α]19D + 47.7° (EtOH) and yields crystalline salts and derivatives: hydrobromide, m.p. 21SoC; aurichloride, m.p. 207°C (dec.); perchlorate, m.p. 240°C (dec.); picrate, m.p. 21SoC and the methochloride aurichloride, m.p. 18SoC (dec.). Ochiai and Ito have shown that it is formed by the action of hydrogen peroxide on Matrine (q.v.), indicating that its structure is matrine-N-oxide.

Description

Oxymatrine is a natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B alone and in combination with lamivudine. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of nuclear factors-κB.

The Uses of Ammothamnine

antifungal, hepatoprotectant

The Uses of Ammothamnine

Oxymatrine is a an anti-tumor agent triggering apoptosis in human leukemia cells.

What are the applications of Application

Oxymatrine is an inhibitor of IL-6 and IL-1β mRNA expression

Definition

ChEBI: Ammothamnine is an alkaloid and a tertiary amine oxide.

References

Kondo et al., Arch. Pharm., 275,493 (1937)
Ochiai, Ito., Ber., 81,938 (1938)

Properties of Ammothamnine

Melting point: 208℃
storage temp.  Inert atmosphere,2-8°C
solubility  methanol: soluble10mg/mL, clear, colorless
pka 4.87±0.20(Predicted)
form  powder
color  white to off-white
Stability: Hygroscopic

Safety information for Ammothamnine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P270:Do not eat, drink or smoke when using this product.
P330:Rinse mouth.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P403:Store in a well-ventilated place.

Computed Descriptors for Ammothamnine

InChIKey XVPBINOPNYFXID-LHDUFFHYSA-N

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