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HomeProduct name listSCUTELLAREIN

SCUTELLAREIN

Synonym(s):4′,5,6,7-Tetrahydroxyflavone;6-Hydroxyapigenin

  • CAS NO.:529-53-3
  • Empirical Formula: C15H10O6
  • Molecular Weight: 286.24
  • MDL number: MFCD00017692
  • EINECS: 1806241-263-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
SCUTELLAREIN Structural

What is SCUTELLAREIN?

Description

Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM. In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.

Chemical properties

Yellow solid

The Uses of SCUTELLAREIN

Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue.

Definition

ChEBI: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.

Properties of SCUTELLAREIN

Melting point: 330°C
Boiling point: 642.9±55.0 °C(Predicted)
Density  1.654±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
solubility  DMSO: soluble1mg/mL, clear, greenish-yellow
pka 6.34±0.40(Predicted)
form  powder
color  yellow

Safety information for SCUTELLAREIN

Computed Descriptors for SCUTELLAREIN

InChIKey JVXZRQGOGOXCEC-UHFFFAOYSA-N

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