3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID

CAS NO.：34576-94-8
Empirical Formula: C9H4Cl2O2S
Molecular Weight: 247.1
MDL number: MFCD00781745
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-18 21:14:07

What is 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID?

Description

3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a K_i value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1. It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).

What are the applications of Application

3,6-Dichloro-benzo[b]thiophene-2-carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) and useful biochemical for proteomics research.

References

1) Tso et al. (2014), Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase; J. Biol. Chem., 289 20583 2) Friberg et al. (2013), Discovery of potent myeloid cell leukemia (Mcl 1) inhibitors using fragment based methods and structure based design; J. Med. Chem. 56 15

Properties of 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID

Boiling point:	426.4±40.0 °C(Predicted)
Density	1.653±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO (up to at least 20 mg/ml)
form	solid
pka	2.09±0.30(Predicted)
color	Off-white
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.