3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
- CAS NO.：34576-94-8
- Empirical Formula: C9H4Cl2O2S
- Molecular Weight: 247.1
- MDL number: MFCD00781745
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-18 21:14:07
![3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Structural](https://img.chemicalbook.in/CAS/GIF/34576-94-8.gif)
What is 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID?
Description
3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1. It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).
What are the applications of Application
3,6-Dichloro-benzo[b]thiophene-2-carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) and useful biochemical for proteomics research.
References
1) Tso et al. (2014), Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase; J. Biol. Chem., 289 20583 2) Friberg et al. (2013), Discovery of potent myeloid cell leukemia (Mcl 1) inhibitors using fragment based methods and structure based design; J. Med. Chem. 56 15
Properties of 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
| Boiling point: | 426.4±40.0 °C(Predicted) |
| Density | 1.653±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to at least 20 mg/ml) |
| form | solid |
| pka | 2.09±0.30(Predicted) |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
Computed Descriptors for 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![3,4,6-trichloro-7-fluorobenzo[b]thiophene-2-carboxylic acid](https://img.chemicalbook.in/CAS/20200401/GIF/CB31558628.gif)
![METHYL 3,4,6-TRICHLOROBENZO[B]THIOPHENE-2-CARBOXYLATE](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB8716448.gif)
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