3,4-Dichloro-1,2,5-thiadiazole

CAS NO.：5728-20-1
Empirical Formula: C2Cl2N2S
Molecular Weight: 155.01
MDL number: MFCD00010072
EINECS: 227-232-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-09 09:30:26

What is 3,4-Dichloro-1,2,5-thiadiazole?

Chemical properties

Colorless liquid

The Uses of 3,4-Dichloro-1,2,5-thiadiazole

3,4-Dichloro-1,2,5-thiadiazole is a chlorinated thiadiazole that is a potent inhibitors of nitrification in soil. 3,4-Dichloro-1,2,5-thiadiazole is used as a building block in the preparaton of the β-adrenergic blocking agent, Timolol (T443700).

The Uses of 3,4-Dichloro-1,2,5-thiadiazole

3,4-Dichloro-1,2,5-thiadiazole has been employed:

as guest molecule to investigate solid-state 13C NMR spectra of inclusion compounds of 2,6-dimethyl-bicyclo[3.3.1]nonane-exo-2-exo-6-diol with small organic molecules
in preparation of [1,2,5]thiadiazol-3-yl-piperazine compounds

Synthesis Reference(s)

Tetrahedron Letters, 15, p. 1687, 1974 DOI: 10.1016/S0040-4039(01)82554-5

Properties of 3,4-Dichloro-1,2,5-thiadiazole

Melting point:	82-83 °C
Boiling point:	158 °C (lit.)
Density	1.648 g/mL at 25 °C (lit.)
refractive index	1.561
Flash point:	>100°C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in chloroform and methanol.
form	Oil
pka	-3.82±0.10(Predicted)
color	Colorless
Sensitive	Hygroscopic
BRN	606585
CAS DataBase Reference	5728-20-1(CAS DataBase Reference)

Safety information for 3,4-Dichloro-1,2,5-thiadiazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.