3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
Synonym(s):Di(N-succinimidyl) 3,3′-dithiodipropionate;Dithiobis(succinimidyl propionate);DTSP;Lomant’s reagent
- CAS NO.:57757-57-0
- Empirical Formula: C14H16N2O8S2
- Molecular Weight: 404.42
- MDL number: MFCD00042045
- EINECS: 260-931-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:02
What is 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)?
Description
DSP Crosslinker is a cleavable crosslinker. It contains two terminal NHS ester moieties which can react with primary amines. The disulfide bonds can be cleaved via a reduction reaction using Dithiothreitol (DTT) reagent.
Chemical properties
Off-White Solid
The Uses of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used in the crosslinking of intracellular proteins prior to cell lysis.
The Uses of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used as amine reactive homobifunctional cross-linking reagent, cleavable under mild conditions with hydroxylamine (pH 8.5, 3-6 h, 37oC)
The Uses of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) has been used as a protein cross-linker.
What are the applications of Application
3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) is a cleavable disulfide linkage-containing homobifunctional cross-linking reagent
General Description
3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) is a homobifunctional cross-linking reagent containing a cleavable disulfide linkage. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5).
Properties of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
Melting point: | 128-133 °C |
Boiling point: | 560.1±60.0 °C(Predicted) |
Density | 1.57±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | chloroform: 50 mg/mL |
form | powder |
color | Off-White |
BRN | 1518074 |
CAS DataBase Reference | 57757-57-0(CAS DataBase Reference) |
Safety information for 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
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