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HomeProduct name list3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

Synonym(s):Di(N-succinimidyl) 3,3′-dithiodipropionate;Dithiobis(succinimidyl propionate);DTSP;Lomant’s reagent

  • CAS NO.:57757-57-0
  • Empirical Formula: C14H16N2O8S2
  • Molecular Weight: 404.42
  • MDL number: MFCD00042045
  • EINECS: 260-931-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 09:03:02
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) Structural

What is 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)?

Description

DSP Crosslinker is a cleavable crosslinker. It contains two terminal NHS ester moieties which can react with primary amines. The disulfide bonds can be cleaved via a reduction reaction using Dithiothreitol (DTT) reagent.

Chemical properties

Off-White Solid

The Uses of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used in the crosslinking of intracellular proteins prior to cell lysis.

The Uses of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used as amine reactive homobifunctional cross-linking reagent, cleavable under mild conditions with hydroxylamine (pH 8.5, 3-6 h, 37oC)

The Uses of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) has been used as a protein cross-linker.

What are the applications of Application

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) is a cleavable disulfide linkage-containing homobifunctional cross-linking reagent

General Description

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) is a homobifunctional cross-linking reagent containing a cleavable disulfide linkage. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5).

Properties of 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

Melting point: 128-133 °C
Boiling point: 560.1±60.0 °C(Predicted)
Density  1.57±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  chloroform: 50 mg/mL
form  powder
color  Off-White
BRN  1518074
CAS DataBase Reference 57757-57-0(CAS DataBase Reference)

Safety information for 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)

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