DISUCCINIMIDYL SUBERATE
Synonym(s):Disuccinimidyl octanedioate;Disuccinimidyl suberate;Disuccinimidyl suberate (DSS)
- CAS NO.:68528-80-3
- Empirical Formula: C16H20N2O8
- Molecular Weight: 368.34
- MDL number: MFCD00049059
- EINECS: 614-576-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is DISUCCINIMIDYL SUBERATE?
Description
DSS Crosslinker is a membrane permeable, noncleavable crosslinker. The NHS ester groups are reactive toward primary amines.
The Uses of DISUCCINIMIDYL SUBERATE
Disuccinimidyl suberate (DSS) is a bifunctional cross-linking reagent which contains two N-hydroxysuccinimide esters that are reactive toward primary amines. DSS is membrane-permeable and is commonly used to cross-link proteins in intact cells.
The Uses of DISUCCINIMIDYL SUBERATE
Disuccinimidyl suberate is a homobifunctional amine-reactive crosslinker. It is usually coupled to molecules containing primary amines via amide bonds buffered at pH 7.5 (6.5-8.5). It incorporates an 8-atom spacer arm.
The Uses of DISUCCINIMIDYL SUBERATE
Suberic acid bis(N-hydroxysuccinimide ester) has been:
- supplemented in pierce lysis buffer used for immunoprecipitation
- used to conjugate the oligonucleotide standards to gelatin
- used in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers
What are the applications of Application
Suberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional amine-reactive crosslinker, 8 atom spacer arm
General Description
Suberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.
Properties of DISUCCINIMIDYL SUBERATE
Melting point: | 169-170°C |
Boiling point: | 513.5±60.0 °C(Predicted) |
Density | 1.295 g/cm3 |
storage temp. | 2-8°C |
solubility | chloroform: 50 mg/mL |
form | powder |
color | White to Almost white |
Water Solubility | Insoluble in water. Soluble in chloroform: 50 mg/mL. |
CAS DataBase Reference | 68528-80-3 |
Safety information for DISUCCINIMIDYL SUBERATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DISUCCINIMIDYL SUBERATE
InChIKey | ZWIBGKZDAWNIFC-UHFFFAOYSA-N |
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