Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Structural

What is 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol?

The Uses of 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

TG100-115 is a potent and selective phosphoinositide 3-kinase gamma/delta (PI3Kγ/δ) inhibitor. It can provide potent cardioprotection, reduce infarct development, and preserve myocardial function.

What are the applications of Application

TG100-115 is a PI3K and FRAP inhibitor with some action against Akt

Definition

ChEBI: 3-[2,4-diamino-7-(3-hydroxyphenyl)-6-pteridinyl]phenol is a member of pteridines.

Biological Activity

tg100-115 is an inhibitor of pi3kγ and pi3kδ with ic50 values of 83 nm and 235 nm, respectively. tg100-115 shows no obvious activity against pi3kα and pi3kβ [1].tg100-115 remarkably reduced eosinophil accumulation, balf levels of classic th2 cytokine il-13, perivascular and peribronchial leukocyte accumulations, and bronchiolar mucin accumulation in a murine model. besides, tg100-115 showed to reduce airway hyper-responsiveness (ahr) by approximately 50% in asthmatic mice. moreover, tg100-115 has been reported to reduce both smoke-and lps-induced neutrophil and lps-induced classic th1 cytokine tnfα accumulations in mice [2].

References

[1] doukas j1, wrasidlo w, noronha g, dneprovskaia e, fine r, weis s, hood j, demaria a, soll r, cheresh d. hosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. proc natl acad sci u s a. 2006 dec 26;103(52):19866-71.
[2] doukas j1, eide l, stebbins k, racanelli-layton a, dellamary l, martin m, dneprovskaia e, noronha g, soll r, wrasidlo w, acevedo lm, cheresh da. aerosolized phosphoinositide 3-kinase gamma/delta inhibitor tg100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. j pharmacol exp ther. 2009 mar;328(3):758-65.

Properties of 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

Boiling point: 699.6±65.0 °C(Predicted)
Density  1.516±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  insoluble in H2O; insoluble in EtOH; ≥3.46 mg/mL in DMSO
pka 8.54±0.10(Predicted)
form  Yellow powder solid.
color  Light yellow to yellow

Safety information for 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

Computed Descriptors for 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.