3-(Trifluoromethoxy)bromobenzene

CAS NO.：2252-44-0
Empirical Formula: C7H4BrF3O
Molecular Weight: 241.01
MDL number: MFCD00040943
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-25 17:47:29

What is 3-(Trifluoromethoxy)bromobenzene?

Chemical properties

Clear very faintly yellow liquid

The Uses of 3-(Trifluoromethoxy)bromobenzene

1-Bromo-3-(trifluoromethoxy)benzene may be used in the preparation of 1,2-dehydro-3-(trifluoromethoxy)benzene. It may be used in the synthesis of new electronically deficient atropisomeric diphosphine ligand (S)-CF₃O-BiPhep [2,2′-bis(diphenylphosphino)-6,6′-ditrifluoromethoxy-1,1′-biphenyl].

General Description

1-Bromo-3-(trifluoromethoxy)benzene undergoes Diels-Alder reaction with lithium diisopropylamide (LDA) in THF and furan, to yield the corresponding 1,4-dihydro-1,4-epoxy-5- or 6-(trifluoromethoxy)naphthalenes.

Properties of 3-(Trifluoromethoxy)bromobenzene

Boiling point:	156-158 °C
Density	1.62 g/mL at 25 °C(lit.)
refractive index	n20/D 1.462(lit.)
Flash point:	145 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	1.64
BRN	1945938
CAS DataBase Reference	2252-44-0(CAS DataBase Reference)
NIST Chemistry Reference	3-(Trifluoromethoxy)bromobenzene(2252-44-0)

Safety information for 3-(Trifluoromethoxy)bromobenzene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..…