1,3-Dibromobenzene

CAS NO.：108-36-1
Empirical Formula: C6H4Br2
Molecular Weight: 235.9
MDL number: MFCD00000078
EINECS: 203-574-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-09-09 19:09:56

What is 1,3-Dibromobenzene?

Chemical properties

clear colourless to light yellow liquid

The Uses of 1,3-Dibromobenzene

1,3-Dibromobenzene is used in Suzuki coupling reaction for the preparation of [n]metacyclophanes. It is used to prepare 5-(3-bromo-phenyl)-2,4-di-tert-butoxy-pyrimidine using Pd(0) (PPh3)4 as a reagent. Further, it undergoes solid-supported potassium fluoride-aluminum oxide palladium-catalyzed polyarylation reaction with phenyl boronic acid to get conjugated polyaryls.

Definition

ChEBI: A dibromobenzene carrying bromo groups at positions 1 and 3.

General Description

1,3-Dibromobenzene undergoes solid-supported [KF-Al₂O₃] palladium-catalyzed polyarylation reaction with phenyl boronic acid under microwave irradiation to yield conjugated polyaryls.

Properties of 1,3-Dibromobenzene

Melting point:	-7 °C (lit.)
Boiling point:	218-219 °C (lit.)
Density	1.952 g/mL at 25 °C (lit.)
vapor density	8.16 (vs air)
vapor pressure	5 mm Hg ( 66 °C)
refractive index	n20/D 1.608(lit.)
Flash point:	201 °F
storage temp.	Sealed in dry,Room Temperature
solubility	0.068g/l
form	Liquid
Specific Gravity	1.952
color	Clear colorless to light yellow
Water Solubility	insoluble
BRN	1904538
Dielectric constant	5.0
CAS DataBase Reference	108-36-1(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1,3-dibromo-(108-36-1)
EPA Substance Registry System	m-Dibromobenzene (108-36-1)

Safety information for 1,3-Dibromobenzene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.