3-Hydroxypivalic acid
- CAS NO.：4835-90-9
- Empirical Formula: C5H10O3
- Molecular Weight: 118.13
- MDL number: MFCD00059953
- EINECS: 225-419-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:32
What is 3-Hydroxypivalic acid?
Chemical properties
white crystal
The Uses of 3-Hydroxypivalic acid
3-Hydroxy-2,2-dimethylpropionic acid is used as pharmaceutical intermediate.
Reactions
When 3-Hydroxypivalic acid (1r)
was used under standard conditions, the free hydroxyl group was
well tolerated and after conjugated addition, the lactonization took
place smoothly to afford compound 3ra as a single
diastereoisomer (according to 1H- and 13C-NMR)[1].
Tandem decarboxylation-Giese reaction-lactonization
Flammability and Explosibility
Not classified
References
[1] NIEVES P. RAMIREZ; Jose C G G. Decarboxylative Giese-Type Reaction of Carboxylic Acids Promoted by Visible Light: A Sustainable and Photoredox-Neutral Protocol[J]. European Journal of Organic Chemistry, 2017. DOI:10.1002/ejoc.201601478.
Properties of 3-Hydroxypivalic acid
| Melting point: | −16 °C(lit.) |
| Boiling point: | 164-166 °C20 mm Hg(lit.) |
| Density | 1.221 g/mL at 25 °C(lit.) |
| vapor pressure | 0.446Pa at 25℃ |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Sparingly, Heated), Methanol (Slightly) |
| pka | 4.55±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | Soluble in water. |
| BRN | 1747025 |
| CAS DataBase Reference | 4835-90-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Hydroxy pivalic acid(4835-90-9) |
| EPA Substance Registry System | Hydroxypivalic acid (4835-90-9) |
Safety information for 3-Hydroxypivalic acid
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Hydroxypivalic acid
3-Hydroxypivalic acid manufacturer
BASF India Limited
1Y
Phone:+91-2262785600
product: 4835-90-9 3-Hydroxy-2,2-dimethyl-propionic acid 98%
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