3-Hydroxypivalic acid

CAS NO.：4835-90-9
Empirical Formula: C5H10O3
Molecular Weight: 118.13
MDL number: MFCD00059953
EINECS: 225-419-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is 3-Hydroxypivalic acid?

Chemical properties

white crystal

The Uses of 3-Hydroxypivalic acid

3-Hydroxy-2,2-dimethylpropionic acid is used as pharmaceutical intermediate.

Reactions

When 3-Hydroxypivalic acid (1r) was used under standard conditions, the free hydroxyl group was well tolerated and after conjugated addition, the lactonization took place smoothly to afford compound 3ra as a single diastereoisomer (according to 1H- and 13C-NMR)^[1].
Tandem decarboxylation-Giese reaction-lactonization
3-Hydroxypivalic acid reactions

Flammability and Explosibility

Not classified

References

[1] NIEVES P. RAMIREZ; Jose C G G. Decarboxylative Giese-Type Reaction of Carboxylic Acids Promoted by Visible Light: A Sustainable and Photoredox-Neutral Protocol[J]. European Journal of Organic Chemistry, 2017. DOI:10.1002/ejoc.201601478.

Properties of 3-Hydroxypivalic acid

Melting point:	−16 °C(lit.)
Boiling point:	164-166 °C20 mm Hg(lit.)
Density	1.221 g/mL at 25 °C(lit.)
vapor pressure	0.446Pa at 25℃
refractive index	n20/D 1.5215(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Sparingly, Heated), Methanol (Slightly)
pka	4.55±0.10(Predicted)
form	powder to crystal
color	White to Almost white
Water Solubility	Soluble in water.
BRN	1747025
CAS DataBase Reference	4835-90-9(CAS DataBase Reference)
NIST Chemistry Reference	Hydroxy pivalic acid(4835-90-9)
EPA Substance Registry System	Hydroxypivalic acid (4835-90-9)

Safety information for 3-Hydroxypivalic acid

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.