(2R,3S)-N-Benzoyl-3-phenyl Isoserine
- CAS NO.：132201-33-3
- Empirical Formula: C16H15NO4
- Molecular Weight: 285.3
- MDL number: MFCD00274633
- EINECS: 631-348-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is (2R,3S)-N-Benzoyl-3-phenyl Isoserine?
The Uses of (2R,3S)-N-Benzoyl-3-phenyl Isoserine
(2R,3S)-N-Benzoyl-3-phenylisoserine is an intermediate in the preparation of potent anticancer drug Paclitaxel (P132500) used to study the location of the binding sites. (2R,3S)-N-Benzoyl-3-phenylisoserine shows cytotoxic, antiviral and immunomodulatory activity.
The Uses of (2R,3S)-N-Benzoyl-3-phenyl Isoserine
The presence of this chiral side chain has proven to be essential for the biological activity of taxol, one of the most promising anticancer agents being investigated. The challenging synthesis of taxol has stimulated interest in the attachment of the C-13 side chain to naturally derived taxanes like baccatin III.
Properties of (2R,3S)-N-Benzoyl-3-phenyl Isoserine
| Melting point: | 169-172 °C (lit.) |
| Boiling point: | 580.7±50.0 °C(Predicted) |
| Density | 1.316±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Ethanol (Slightly) |
| form | Solid |
| pka | 3.40±0.17(Predicted) |
| color | White to Off-White |
| optical activity | [α]20/D 40°, c = 1.0 in ethanol |
| CAS DataBase Reference | 132201-33-3(CAS DataBase Reference) |
Safety information for (2R,3S)-N-Benzoyl-3-phenyl Isoserine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (2R,3S)-N-Benzoyl-3-phenyl Isoserine
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