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HomeProduct name list2,6-Dichloropurine

2,6-Dichloropurine

  • CAS NO.:5451-40-1
  • Empirical Formula: C5H2Cl2N4
  • Molecular Weight: 189
  • MDL number: MFCD09749894
  • EINECS: 226-681-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 15:53:33
2,6-Dichloropurine Structural

What is 2,6-Dichloropurine?

Chemical properties

white to light yellow crystal powder

The Uses of 2,6-Dichloropurine

2,6-Dichloropurine is used in the synthesis of 2,6-diamino-substituted purine derivatives as potential cardiomyogenesis inducing agents.

The Uses of 2,6-Dichloropurine

Suzuki-Miyaura cross-coupling between halopurines and arylboronic acids in water-acetonitrile.1

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 404, 1958 DOI: 10.1021/ja01535a040

Purification Methods

It can be recrystallised from 150 parts of boiling H2O and dried at 100o to constant weight. It is soluble in EtOAc. The HgCl2 salt separates from EtOH solution. UV: max 275nm ( 8.9K) at pH 1; and 280nm ( 8.5K) at pH 11 [Elion & Hitchings J Am Chem Soc 78 3508 1956, Schaeffer & Thomas J Am Chem Soc 80 3738 1958, Beaman & Robins J Appl Chem (London) 12 432 1962, Montgomery J Am Chem Soc 78 1928 1956]. [Beilstein 26 III/IV 1747.]

Properties of 2,6-Dichloropurine

Melting point: 185-195 °C (dec.) (lit.)
Boiling point: 310.62°C (rough estimate)
Density  1.7265 (rough estimate)
refractive index  1.6300 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  soluble
pka 5.22±0.20(Predicted)
form  Crystalline Powder
color  White to yellow
Water Solubility  soluble
BRN  9354
CAS DataBase Reference 5451-40-1(CAS DataBase Reference)

Safety information for 2,6-Dichloropurine

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for 2,6-Dichloropurine

InChIKey RMFWVOLULURGJI-UHFFFAOYSA-N

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