2,6-Dichloropurine
- CAS NO.：5451-40-1
- Empirical Formula: C5H2Cl2N4
- Molecular Weight: 189
- MDL number: MFCD09749894
- EINECS: 226-681-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-10 09:15:32
What is 2,6-Dichloropurine?
Chemical properties
white to light yellow crystal powder
The Uses of 2,6-Dichloropurine
Suzuki-Miyaura cross-coupling between halopurines and arylboronic acids in water-acetonitrile.1
The Uses of 2,6-Dichloropurine
2,6-Dichloropurine is used in the synthesis of 2,6-diamino-substituted purine derivatives as potential cardiomyogenesis inducing agents.
Synthesis Reference(s)
Journal of the American Chemical Society, 80, p. 404, 1958 DOI: 10.1021/ja01535a040
Purification Methods
It can be recrystallised from 150 parts of boiling H2O and dried at 100o to constant weight. It is soluble in EtOAc. The HgCl2 salt separates from EtOH solution. UV: max 275nm ( 8.9K) at pH 1; and 280nm ( 8.5K) at pH 11 [Elion & Hitchings J Am Chem Soc 78 3508 1956, Schaeffer & Thomas J Am Chem Soc 80 3738 1958, Beaman & Robins J Appl Chem (London) 12 432 1962, Montgomery J Am Chem Soc 78 1928 1956]. [Beilstein 26 III/IV 1747.]
Properties of 2,6-Dichloropurine
| Melting point: | 185-195 °C (dec.) (lit.) |
| Boiling point: | 310.62°C (rough estimate) |
| Density | 1.7265 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble |
| pka | 5.22±0.20(Predicted) |
| form | Crystalline Powder |
| color | White to yellow |
| Water Solubility | soluble |
| BRN | 9354 |
| CAS DataBase Reference | 5451-40-1(CAS DataBase Reference) |
Safety information for 2,6-Dichloropurine
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 2,6-Dichloropurine
| InChIKey | RMFWVOLULURGJI-UHFFFAOYSA-N |
2,6-Dichloropurine manufacturer
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product: 2,6-Dichloropurine 5451-40-1 98%
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