2,6-Dichloropurine

CAS NO.：5451-40-1
Empirical Formula: C5H2Cl2N4
Molecular Weight: 189
MDL number: MFCD09749894
EINECS: 226-681-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-15 19:00:21

What is 2,6-Dichloropurine?

Chemical properties

white to light yellow crystal powder

The Uses of 2,6-Dichloropurine

2,6-Dichloropurine is used in the synthesis of 2,6-diamino-substituted purine derivatives as potential cardiomyogenesis inducing agents.

The Uses of 2,6-Dichloropurine

Suzuki-Miyaura cross-coupling between halopurines and arylboronic acids in water-acetonitrile.1

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 404, 1958 DOI: 10.1021/ja01535a040

Purification Methods

It can be recrystallised from 150 parts of boiling H2O and dried at 100o to constant weight. It is soluble in EtOAc. The HgCl2 salt separates from EtOH solution. UV: max 275nm ( 8.9K) at pH 1; and 280nm ( 8.5K) at pH 11 [Elion & Hitchings J Am Chem Soc 78 3508 1956, Schaeffer & Thomas J Am Chem Soc 80 3738 1958, Beaman & Robins J Appl Chem (London) 12 432 1962, Montgomery J Am Chem Soc 78 1928 1956]. [Beilstein 26 III/IV 1747.]

Properties of 2,6-Dichloropurine

Melting point:	185-195 °C (dec.) (lit.)
Boiling point:	310.62°C (rough estimate)
Density	1.7265 (rough estimate)
refractive index	1.6300 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble
pka	5.22±0.20(Predicted)
form	Crystalline Powder
color	White to yellow
Water Solubility	soluble
BRN	9354
CAS DataBase Reference	5451-40-1(CAS DataBase Reference)

Safety information for 2,6-Dichloropurine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. P501:Dispose of contents/container to..…