2,5-Dichloropyrimidine
- CAS NO.:22536-67-0
- Empirical Formula: C4H2Cl2N2
- Molecular Weight: 148.98
- MDL number: MFCD00673131
- EINECS: 639-415-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-26 17:49:17
What is 2,5-Dichloropyrimidine?
The Uses of 2,5-Dichloropyrimidine
2,5-Dichloropyrimidine acid is employed as a important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.
Preparation
2,5-Dichloropyrimidine was synthesised from 2-hydroxypyrimidine hydrochloride by treatment with aqueous chlorine solution. Reaction of the product with phosphoryl chloride in the presence of N,N-dimethylaniline gave the desired product in 40% yield. The sample was then purified by sublimation.
storage
Store in cool, dry place in tightly closed container. With adequate ventilation. Store away from oxidizing agent.
structure and hydrogen bonding
C4H2Cl2N2, M=148.98 monoclinic, space group P21/m with a=6.077(3), b=19.771(8), c=7.399(3) ?, β=101.23(6)°, U=872 ?3 [from 2θ values of 29 reflections measured at±ω, 25 ≤2θ ≤ 38°, λ = 0.710 73?, T=150.0 K], Dcalc=1.702 g cm-3, Z=6, μ =0.993 mm-1[1].
References
[1] Blake A, et al. Structure Analysis Restrained by ab Initio Calculations: The Molecular Structure of 2,5-Dichloropyrimidine in Gaseous and Crystalline Phases. The Journal of Physical Chemistry, 1996; 100: 12280–12287.
Properties of 2,5-Dichloropyrimidine
Melting point: | 48-55 °C |
Boiling point: | 190°C |
Density | 1.493 |
Flash point: | 140°C |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
form | Powder |
pka | -2.84±0.22(Predicted) |
color | Off-white |
Water Solubility | Slightly soluble in water. |
λmax | 268nm(EtOH)(lit.) |
InChI | InChI=1S/C4H2Cl2N2/c5-3-1-7-4(6)8-2-3/h1-2H |
CAS DataBase Reference | 22536-67-0(CAS DataBase Reference) |
Safety information for 2,5-Dichloropyrimidine
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H318:Serious eye damage/eye irritation H400:Hazardous to the aquatic environment, acute hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 2,5-Dichloropyrimidine
InChIKey | CEJAHXLRNZJPQH-UHFFFAOYSA-N |
SMILES | C1(Cl)=NC=C(Cl)C=N1 |
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