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HomeProduct name list2,5-Dichloropyrimidine

2,5-Dichloropyrimidine

  • CAS NO.:22536-67-0
  • Empirical Formula: C4H2Cl2N2
  • Molecular Weight: 148.98
  • MDL number: MFCD00673131
  • EINECS: 639-415-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-26 17:49:17
2,5-Dichloropyrimidine Structural

What is 2,5-Dichloropyrimidine?

The Uses of 2,5-Dichloropyrimidine

2,5-Dichloropyrimidine acid is employed as a important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Preparation

2,5-Dichloropyrimidine was synthesised from 2-hydroxypyrimidine hydrochloride by treatment with aqueous chlorine solution. Reaction of the product with phosphoryl chloride in the presence of N,N-dimethylaniline gave the desired product in 40% yield. The sample was then purified by sublimation.

storage

Store in cool, dry place in tightly closed container. With adequate ventilation. Store away from oxidizing agent.

structure and hydrogen bonding

C4H2Cl2N2, M=148.98 monoclinic, space group P21/m with a=6.077(3), b=19.771(8), c=7.399(3) ?, β=101.23(6)°, U=872 ?3 [from 2θ values of 29 reflections measured at±ω, 25 ≤2θ ≤ 38°, λ = 0.710 73?, T=150.0 K], Dcalc=1.702 g cm-3, Z=6, μ =0.993 mm-1[1].

References

[1] Blake A, et al. Structure Analysis Restrained by ab Initio Calculations: The Molecular Structure of 2,5-Dichloropyrimidine in Gaseous and Crystalline Phases. The Journal of Physical Chemistry, 1996; 100: 12280–12287.

Properties of 2,5-Dichloropyrimidine

Melting point: 48-55 °C
Boiling point: 190°C
Density  1.493
Flash point: 140°C
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
form  Powder
pka -2.84±0.22(Predicted)
color  Off-white
Water Solubility  Slightly soluble in water.
λmax 268nm(EtOH)(lit.)
InChI InChI=1S/C4H2Cl2N2/c5-3-1-7-4(6)8-2-3/h1-2H
CAS DataBase Reference 22536-67-0(CAS DataBase Reference)

Safety information for 2,5-Dichloropyrimidine

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H302:Acute toxicity,oral
H318:Serious eye damage/eye irritation
H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 2,5-Dichloropyrimidine

InChIKey CEJAHXLRNZJPQH-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C(Cl)C=N1

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