2,5-Dichloronitrobenzene
Synonym(s):2,5-Dichloronitrobenzene;Nitro-p-dichlorobenzene
- CAS NO.：89-61-2
- Empirical Formula: C6H3Cl2NO2
- Molecular Weight: 192
- MDL number: MFCD00007074
- EINECS: 201-923-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-20 16:46:35
What is 2,5-Dichloronitrobenzene?
Chemical properties
yellow flakes
The Uses of 2,5-Dichloronitrobenzene
2,5-Dichloronitrobenzene is a reagent used in the synthesis of antitrypanosomal, antileishmanial and antimalarial agents. Also it is used in the synthesis of lysophosphatidic acid acyltransferase-β in hibitors.
The Uses of 2,5-Dichloronitrobenzene
2,5-Dichloronitrobenzene is a reagent used in the synthesis of antitrypanosomal, antileishmanial and antimalarial agents. Also it is used in the synthesis of lysophosphatidic acid acyltransferase-β inhibitors.
Production Methods
Nitration of 1,4-dichlorobenzene with mixed acid at 35 – 65 ℃ results in a 98 % yield of essentially pure 2,5-Dichloronitrobenzene.
Purification Methods
Crystallise the nitrobenzene from absolute EtOH. [Beilstein 5 IV 726.]
Properties of 2,5-Dichloronitrobenzene
| Melting point: | 52-54 °C(lit.) |
| Boiling point: | 267 °C |
| Density | 1,442 g/cm3 |
| vapor density | 6.6 (vs air) |
| vapor pressure | <0.1 mm Hg ( 25 °C) |
| refractive index | 1.4390 (estimate) |
| Flash point: | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | 0.083g/l |
| form | neat |
| color | Pale Yellow |
| explosive limit | 2.4-8.5%(V) |
| Water Solubility | Soluble in water, ethanol, ether, benzene, carbon disulfide. Slightly soluble in carbon tetrachloride. |
| BRN | 778109 |
| CAS DataBase Reference | 89-61-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1,4-dichloro-2-nitro-(89-61-2) |
| IARC | 2B (Vol. 65, 123) 2020 |
| EPA Substance Registry System | 2,5-Dichloronitrobenzene (89-61-2) |
Safety information for 2,5-Dichloronitrobenzene
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for 2,5-Dichloronitrobenzene
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