2,5-Dichloronitrobenzene

Synonym(s):2,5-Dichloronitrobenzene;Nitro-p-dichlorobenzene

CAS NO.：89-61-2
Empirical Formula: C6H3Cl2NO2
Molecular Weight: 192
MDL number: MFCD00007074
EINECS: 201-923-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-20 16:46:35

What is 2,5-Dichloronitrobenzene?

Chemical properties

yellow flakes

The Uses of 2,5-Dichloronitrobenzene

2,5-Dichloronitrobenzene is a reagent used in the synthesis of antitrypanosomal, antileishmanial and antimalarial agents. Also it is used in the synthesis of lysophosphatidic acid acyltransferase-β in hibitors.

The Uses of 2,5-Dichloronitrobenzene

Production Methods

Nitration of 1,4-dichlorobenzene with mixed acid at 35 – 65 ℃ results in a 98 % yield of essentially pure 2,5-Dichloronitrobenzene.

Purification Methods

Crystallise the nitrobenzene from absolute EtOH. [Beilstein 5 IV 726.]

Properties of 2,5-Dichloronitrobenzene

Melting point:	52-54 °C(lit.)
Boiling point:	267 °C
Density	1,442 g/cm³
vapor density	6.6 (vs air)
vapor pressure	<0.1 mm Hg ( 25 °C)
refractive index	1.4390 (estimate)
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	0.083g/l
form	neat
color	Pale Yellow
explosive limit	2.4-8.5%(V)
Water Solubility	Soluble in water, ethanol, ether, benzene, carbon disulfide. Slightly soluble in carbon tetrachloride.
BRN	778109
CAS DataBase Reference	89-61-2(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1,4-dichloro-2-nitro-(89-61-2)
IARC	2B (Vol. 65, 123) 2020
EPA Substance Registry System	2,5-Dichloronitrobenzene (89-61-2)

Safety information for 2,5-Dichloronitrobenzene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment.