Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list2,4-Dihydroxyacetophenone

2,4-Dihydroxyacetophenone

Synonym(s):1-Acetyl-2,4-dihydroxybenzene;4-Acetylresorcinol;Resacetophenone

  • CAS NO.:89-84-9
  • Empirical Formula: C8H8O3
  • Molecular Weight: 152.15
  • MDL number: MFCD00002279
  • EINECS: 201-945-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2025-01-27 09:38:02
2,4-Dihydroxyacetophenone Structural

What is 2,4-Dihydroxyacetophenone?

Chemical properties

2,4-Dihydroxyacetophenone appears as a yellow-brown to reddish-brown fine crystalline powder. It slowly decomposes in water and can dissolve in hot alcohol, pyridine, and glacial acetic acid. In contrast, it is nearly insoluble in ether, benzene, and chloroform. A reaction with iron chloride causes it to adopt a red hue.

The Uses of 2,4-Dihydroxyacetophenone

2,4-Dihydroxyacetophenone is used as intermediate for pharmaceuticals.

The Uses of 2,4-Dihydroxyacetophenone

2,4-Dihydroxyacetophenone (cas# 89-84-9) is a compound useful in organic synthesis. It is also used as intermediate for pharmaceuticals. Reagent for iron as a 10% alcoholic solution. A red color is obtained with ferric ions in slightly acid solution: Cooper, Ind. Eng. Chem. Anal. Ed. 9, 334 (1937).

Definition

ChEBI: 2',4'-dihydroxyacetophenone is a dihydroxyacetophenone that is acetophenone carrying hydroxy substituents at positions 2' and 4'. It has a role as a plant metabolite. It is a member of resorcinols and a dihydroxyacetophenone.

Preparation

Preparation by reaction of acetic acid on resorcinol,
with zinc chloride (Nencki reaction) (94%)
with boron trifluoride
with Amberlite IR-120 (a cation exchange resin, sulfonic acid type) (87%)
with polyphosphoric acid (63%)
with 70% perchloric acid (33%).

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 428, 1948 DOI: 10.1021/ja01181a521

Safety Profile

Moderately toxic by ingestion. Experimental reproductive effects. A severe eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Synthesis

2,4-Dihydroxyacetophenone is obtained by the acetylation of resorcinol and acetic acid. In addition, it can also be obtained by reacting resorcinol with chloroacetyl or acetic anhydride in the presence of zinc chloride.

Properties of 2,4-Dihydroxyacetophenone

Melting point: 143-144.5 °C(lit.)
Boiling point: 234.6°C (rough estimate)
Density  1.18 g/mL at 25 °C(lit.)
refractive index  1.4945 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO (Slightly), Methanol (Slightly)
pka 7.96±0.18(Predicted)
form  Crystalline Powder or Crystals
color  Off-white to pink to brown
PH 5 (1g/l, H2O, 20℃)
Sensitive  Moisture Sensitive
Merck  14,8140
BRN  1282505
CAS DataBase Reference 89-84-9(CAS DataBase Reference)
NIST Chemistry Reference Ethanone, 1-(2,4-dihydroxyphenyl)-(89-84-9)
EPA Substance Registry System Ethanone, 1-(2,4-dihydroxyphenyl)- (89-84-9)

Safety information for 2,4-Dihydroxyacetophenone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 2,4-Dihydroxyacetophenone

InChIKey SULYEHHGGXARJS-UHFFFAOYSA-N

2,4-Dihydroxyacetophenone manufacturer

ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED

2Y
Phone:+91-9966658228
Whatsapp: +91- 9966658228
product: 89-84-9 2,4-Dihydroxy acetophenone 99%
Inquiry

PEE ESS AROMATICS

2Y
Phone:+91-9382160846
Whatsapp: +91- 9382160846
product: 89-84-9 99%
Inquiry

Millennium Chemi Pharma (Mysore) Pvt Ltd

1Y
Phone:+918212582039
Whatsapp: +91-8212582039
product: 89-84-9 2,4-Dihydroxy acetophenone 98%
Inquiry

HYPERSYNTH LIFE SCIENCES

1Y
Phone:+91-9989233308
Whatsapp: +91-9989233308
product: 89-84-9 2,4-Dihydroxy acetophenone 99%
Inquiry

Aion Pharma LLP

1Y
Phone:+91-9703121636
Whatsapp: +91- 9703121636
product:
Inquiry

Anand Agencies

Maharashtra
Phone:91-9075014125
Whatsapp: 91-9075014125
product: 2,4-Dihydroxy acetophenone
Inquiry

Suvchem

Maharashtra
Phone:91-9821198699
Whatsapp: 91-9821198699
product: 2,4-Dihydroxy acetophenone
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.