2,4-Dichloropyridine

Chemical properties

Light yellow liquid

The Uses of 2,4-Dichloropyridine

2,4-Dichloropyridine is a versatile reactant used in the preparation of host materials for light-emitting diodes with heterocyclic cores. Also used in the preparation of sulfonylated pyridines, pyrazine and quinoline via aromatic nucleophilic substitution of azines with sodium sulfinates.

Synthesis

Add 1000 mg of 2,4-dihydroxypyrimidine (8.9 mmol) to a 50 mL reaction flask.50mg DMAP and 4mL SOCl2,A turbid liquid is formed. A solution of 5.28 g (17.8 mmol) of BTC in SOCl 2 (4 mL) was slowly added dropwise.Heating in an oil bath, controlling the reaction temperature between 65 and 70 ° C,Cooling reflux reaction with frozen liquid. After the reaction was completed until the reaction of the starting material was completed, the reaction mixture was cooled, and the solvent was evaporated, and then added to 10 mL of ice water, neutralized with sodium carbonate solution to pH = 8 to 9, and extracted with dichloromethane, and the organic layer was separated.After washing with water, brine, and dried over anhydrous sodium sulfate, the solvent was evaporated (or purified) to give 2,4-dichloropyrimidine in a yield of 95%.