2,6-Dichloropyridine
- CAS NO.：2402-78-0
- Empirical Formula: C5H3Cl2N
- Molecular Weight: 147.99
- MDL number: MFCD00006244
- EINECS: 219-282-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-29 22:41:02
What is 2,6-Dichloropyridine?
Description
2,6-Dichloropyridine is an important intermediate that is widely used in the medicine and pesticide research field. It could be used as a starting material to synthesize the pirozadil (Pirozadil) which can be used for reducing blood-fat, and antiplatelet condensation. 2,6-dichloropyridine also can be used to synthetic musk pyridine with alternative natural musk. 2,3,5, 6-TCP produced by further chlorination of 2, 6-dichloropyridine is an important raw material for chlorpyrifos, which is widely used in the world with high efficiency, broad spectrum, and low residue.
Synthesis
2-chloropyridine or 2-chloropyridine hydrochloride reacting with chlorine under photoinitiation actions at 160-190 ℃ to generate the 2,6-dichloropyridine.
Chemical properties
White to light yellow solid
The Uses of 2,6-Dichloropyridine
2,6-Dichloropyridine is used in the preparation of triazolo and imidazo potassium channel antagonists as antiarrythmic agents.
Purification Methods
It crystallises from EtOH. [Beilstein 20/5 V 416.]
Properties of 2,6-Dichloropyridine
| Melting point: | 83-86 °C (lit.) |
| Boiling point: | 211 °C |
| Density | 1.5159 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point: | 110°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | methanol: 50 mg/mL, clear |
| form | Crystalline Powder |
| pka | -3.02±0.10(Predicted) |
| color | White to pink or grayish-white |
| PH | 6-7 (H2O, 20℃)(saturated solution) |
| Water Solubility | <1 g/L (20 ºC) |
| BRN | 108664 |
| CAS DataBase Reference | 2402-78-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridine, 2,6-dichloro-(2402-78-0) |
| EPA Substance Registry System | 2,6-Dichloropyridine (2402-78-0) |
Safety information for 2,6-Dichloropyridine
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,6-Dichloropyridine
| InChIKey | FILKGCRCWDMBKA-UHFFFAOYSA-N |
Abamectin manufacturer
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