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HomeProduct name list2,3-Dichloropyridine

2,3-Dichloropyridine

  • CAS NO.:2402-77-9
  • Empirical Formula: C5H3Cl2N
  • Molecular Weight: 147.99
  • MDL number: MFCD00006229
  • EINECS: 219-281-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
2,3-Dichloropyridine Structural

What is 2,3-Dichloropyridine?

Chemical properties

White to slightly beige crystalline powder

The Uses of 2,3-Dichloropyridine

2,3-Dichloropyridine is used as a reagent for the preparation of substituted 3-(5-membered heterocycle-carboxamido)pyridine derivatives for treatment of autoimmune and inflammatory diseases. Also in the synthesis, crystal structure and biological activity of novel anthranilic Diamide insecticide with propargyl ether.

Synthesis

2,3-dichloropyridine is synthesized from 2-chloronicotinic acid via amidation, Hofmann degradation, diazotization and Sandmeyer reaction.

Description

2,3-Dichloropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Structure and conformation

The complete mol-ecule of 2,3-Dichloropyridine, C5H3Cl2N, is generated by crystallographic twofold symmetry, which forces the pyridine N atom and the opposite C—H group to be statistically disordered. In the crystal, weak aromatic π–π stacking [centroid–centroid separation = 3.805 (4)Å and slippage = 1.704Å] leads to [100] stacks of mol-ecules. Short Cl···Cl contacts [3.334 (3)Å] are also observed. Colourless prisms were grown from ethanol.
2,3-Dichloropyridine

Properties of 2,3-Dichloropyridine

Melting point: 64-67 °C (lit.)
Boiling point: 242.42°C (rough estimate)
Density  1.5159 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  Inert atmosphere,Room Temperature
form  Crystalline Powder
pka -0.63±0.10(Predicted)
color  White to slightly beige
Water Solubility  slightly soluble
BRN  109811
InChI InChI=1S/C5H3Cl2N/c6-4-2-1-3-8-5(4)7/h1-3H
CAS DataBase Reference 2402-77-9(CAS DataBase Reference)

Safety information for 2,3-Dichloropyridine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2,3-Dichloropyridine

InChIKey MAKFMOSBBNKPMS-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC=C1Cl

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