2,3-Dichloropyridine
- CAS NO.:2402-77-9
- Empirical Formula: C5H3Cl2N
- Molecular Weight: 147.99
- MDL number: MFCD00006229
- EINECS: 219-281-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 2,3-Dichloropyridine?
Chemical properties
White to slightly beige crystalline powder
The Uses of 2,3-Dichloropyridine
2,3-Dichloropyridine is used as a reagent for the preparation of substituted 3-(5-membered heterocycle-carboxamido)pyridine derivatives for treatment of autoimmune and inflammatory diseases. Also in the synthesis, crystal structure and biological activity of novel anthranilic Diamide insecticide with propargyl ether.
Synthesis
2,3-dichloropyridine is synthesized from 2-chloronicotinic acid via amidation, Hofmann degradation, diazotization and Sandmeyer reaction.
Description
2,3-Dichloropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Structure and conformation
The complete mol-ecule of 2,3-Dichloropyridine, C5H3Cl2N, is generated by crystallographic twofold symmetry, which forces the pyridine N atom and the opposite C—H group to be statistically disordered. In the crystal, weak aromatic π–π stacking [centroid–centroid separation = 3.805 (4)Å and slippage = 1.704Å] leads to [100] stacks of mol-ecules. Short Cl···Cl contacts [3.334 (3)Å] are also observed. Colourless prisms were grown from ethanol.
Properties of 2,3-Dichloropyridine
Melting point: | 64-67 °C (lit.) |
Boiling point: | 242.42°C (rough estimate) |
Density | 1.5159 (rough estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
form | Crystalline Powder |
pka | -0.63±0.10(Predicted) |
color | White to slightly beige |
Water Solubility | slightly soluble |
BRN | 109811 |
InChI | InChI=1S/C5H3Cl2N/c6-4-2-1-3-8-5(4)7/h1-3H |
CAS DataBase Reference | 2402-77-9(CAS DataBase Reference) |
Safety information for 2,3-Dichloropyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,3-Dichloropyridine
InChIKey | MAKFMOSBBNKPMS-UHFFFAOYSA-N |
SMILES | C1(Cl)=NC=CC=C1Cl |
Abamectin manufacturer
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
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