2,5-Dichloropyridine
- CAS NO.：16110-09-1
- Empirical Formula: C5H3Cl2N
- Molecular Weight: 147.99
- MDL number: MFCD00006239
- EINECS: 240-278-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-25 23:13:37
What is 2,5-Dichloropyridine?
Chemical properties
white to slightly yellow crystalline solid
The Uses of 2,5-Dichloropyridine
2,5-Dichloropyridine was used in the synthesis of 6-halo-pyridin-3-yl boronic acids and esters. It undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.
Synthesis Reference(s)
Synthetic Communications, 20, p. 2971, 1990 DOI: 10.1080/00397919008051514
General Description
2,5-Dichloropyridine undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.
Properties of 2,5-Dichloropyridine
| Melting point: | 59-62 °C (lit.) |
| Boiling point: | 190-191 °C |
| Density | 1.5159 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point: | 112 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | -2.25±0.10(Predicted) |
| form | Crystalline Solid |
| color | White to slightly yellow |
| Water Solubility | insoluble |
| BRN | 108886 |
| CAS DataBase Reference | 16110-09-1(CAS DataBase Reference) |
Safety information for 2,5-Dichloropyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,5-Dichloropyridine
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