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HomeProduct name list2,5-Dichloropyridine

2,5-Dichloropyridine

  • CAS NO.:16110-09-1
  • Empirical Formula: C5H3Cl2N
  • Molecular Weight: 147.99
  • MDL number: MFCD00006239
  • EINECS: 240-278-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-25 23:13:37
2,5-Dichloropyridine Structural

What is 2,5-Dichloropyridine?

Chemical properties

white to slightly yellow crystalline solid

The Uses of 2,5-Dichloropyridine

2,5-Dichloropyridine was used in the synthesis of 6-halo-pyridin-3-yl boronic acids and esters. It undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.

Synthesis Reference(s)

Synthetic Communications, 20, p. 2971, 1990 DOI: 10.1080/00397919008051514

General Description

2,5-Dichloropyridine undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.

Properties of 2,5-Dichloropyridine

Melting point: 59-62 °C (lit.)
Boiling point: 190-191 °C
Density  1.5159 (rough estimate)
refractive index  1.5500 (estimate)
Flash point: 112 °C
storage temp.  Inert atmosphere,Room Temperature
pka -2.25±0.10(Predicted)
form  Crystalline Solid
color  White to slightly yellow
Water Solubility  insoluble
BRN  108886
CAS DataBase Reference 16110-09-1(CAS DataBase Reference)

Safety information for 2,5-Dichloropyridine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2,5-Dichloropyridine

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