2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside
Synonym(s):2,3,5,4′-Tetrahydroxystilbene 2-O-β-D-glucoside;2,4-Dihydroxy-6-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl β-D-Glucopyranoside;EH-201;Tetrahydroxystilbene glucoside;THSG
- CAS NO.:82373-94-2
- Empirical Formula: C20H22O9
- Molecular Weight: 406.39
- MDL number: MFCD00238694
- EINECS: 683-231-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-03 18:42:19
What is 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside?
The Uses of 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside
2,3,4'',5-Tetrahydroxystilbene 2-O-Glucoside is a scavenging agent, that attenuates free radicals and upregulate antioxidant?/detoxifying enzymes to protect against oxidative damage. It also protects UB/OC-2 cells from H2O2-induced autophagy and apoptosis in vitro.
Definition
ChEBI: (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside is a stilbenoid that is trans-stilbene which has been substituted by hydroxy groups at positions 2, 3, 5, and 4', and in which the hydroxy group at positon 2 has then been converted to the corresponding the beta-D-glucoside. It has a role as an antioxidant, a cyclooxygenase 2 inhibitor, an anti-inflammatory agent, a cardioprotective agent, a platelet aggregation inhibitor and an apoptosis inhibitor. It is a stilbenoid, a beta-D-glucoside and a member of resorcinols.
General Description
2,3,5,4′ -Tetrahydroxystilbene-2-O-beta-glucoside (THSG) is a Polygoni Multiflori based polyphenol.
Biochem/physiol Actions
2,3,5,4′-Tetrahydroxystilbene 2-O-β-D-glucoside induces the expression and enhances the activity of EPO. The compound stimulates mitochondrial biogenesis, and expression of hemoglobin in non-hematopoietic cells. 2,3,5,4′-Tetrahydroxystilbene 2-O-β-D-glucoside has demonstrated protective effects in cardiovascular disease and ischemia models.
Physiological effects
Stilbene glycosides have the functions of brain protection, free radical scavenging, blood lipid lowering, liver protection, anti-tumor, vasodilation, and inhibition of atherosclerosis.
Properties of 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside
Boiling point: | 715.0±60.0 °C(Predicted) |
Density | 1.593±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | H2O: soluble5mg/mL, clear (warmed) |
form | powder |
pka | 8.78±0.40(Predicted) |
color | white to brown |
CAS DataBase Reference | 82373-94-2 |
Safety information for 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside
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