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HomeProduct name list2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside

2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside

Synonym(s):2,3,5,4′-Tetrahydroxystilbene 2-O-β-D-glucoside;2,4-Dihydroxy-6-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl β-D-Glucopyranoside;EH-201;Tetrahydroxystilbene glucoside;THSG

  • CAS NO.:82373-94-2
  • Empirical Formula: C20H22O9
  • Molecular Weight: 406.39
  • MDL number: MFCD00238694
  • EINECS: 683-231-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside Structural

What is 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside?

The Uses of 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside

2,3,4'',5-Tetrahydroxystilbene 2-O-Glucoside is a scavenging agent, that attenuates free radicals and upregulate antioxidant?/detoxifying enzymes to protect against oxidative damage. It also protects UB/OC-2 cells from H2O2-induced autophagy and apoptosis in vitro.

Definition

ChEBI: (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside is a stilbenoid that is trans-stilbene which has been substituted by hydroxy groups at positions 2, 3, 5, and 4', and in which the hydroxy group at positon 2 has then been converted to the corresponding the beta-D-glucoside. It has a role as an antioxidant, a cyclooxygenase 2 inhibitor, an anti-inflammatory agent, a cardioprotective agent, a platelet aggregation inhibitor and an apoptosis inhibitor. It is a stilbenoid, a beta-D-glucoside and a member of resorcinols.

General Description

2,3,5,4′ -Tetrahydroxystilbene-2-O-beta-glucoside (THSG) is a Polygoni Multiflori based polyphenol.

Biochem/physiol Actions

2,3,5,4′-Tetrahydroxystilbene 2-O-β-D-glucoside induces the expression and enhances the activity of EPO. The compound stimulates mitochondrial biogenesis, and expression of hemoglobin in non-hematopoietic cells. 2,3,5,4′-Tetrahydroxystilbene 2-O-β-D-glucoside has demonstrated protective effects in cardiovascular disease and ischemia models.

Physiological effects

Stilbene glycosides have the functions of brain protection, free radical scavenging, blood lipid lowering, liver protection, anti-tumor, vasodilation, and inhibition of atherosclerosis.

Properties of 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside

Boiling point: 715.0±60.0 °C(Predicted)
Density  1.593±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  H2O: soluble5mg/mL, clear (warmed)
form  powder
pka 8.78±0.40(Predicted)
color  white to brown
CAS DataBase Reference 82373-94-2

Safety information for 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside

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