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HomeProduct name listBenzil

Benzil

Synonym(s):Benzil;Dibenzoyl;Diphenylethanedione

  • CAS NO.:134-81-6
  • Empirical Formula: C14H10O2
  • Molecular Weight: 210.23
  • MDL number: MFCD00003080
  • EINECS: 205-157-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:15:30
Benzil Structural

What is Benzil?

Chemical properties

yellow crystals or powder

The Uses of Benzil

Organic synthesis; insecticide.

The Uses of Benzil

Benzil is used as a pharmaceutical intermediate and uv curing resin photosensitizer. In polymer chemistry, it is used as a photoinitiator. Further, it serves as a potent inhibitor of human carboxylesterases. It is used in the preparation of diketimines by reacting with amines. It is also involved in the famous benil-benzilic acid rearrangement. In addition this, it reacts with 1,3-diphenylacetone to get tetraphenylcyclopentadienone.

Definition

A reaction in which benzil (1,2- diphenylethan-1,2-dione) is treated with hydroxide and then with acid to give benzilic acid (2-hydroxy-2,2-diphenylethanoic acid):
C6H5.CO.CO.C6H5
(C6H5)2C(OH).COOH
The reaction, which involves migration of a phenyl group (C6H5-) from one carbon atom to another, was the first rearrangement reaction to be described (by Justus von Liebig in 1828).

Definition

ChEBI: An alpha-diketone that is ethane-1,2-dione substituted by phenyl groups at positions 1 and 2 respectively.

Benefits

Benzil has potential applications in biological metabolism and clinical medicine. Benzil derivates exhibit radical scavenging and antibacterial and hypertensive, antiprotozoal, antiproliferative, and antimitotic activities. Benzil derivatives have versatile applications in the pharmaceutical industry, and various heterocyclic compounds such as triazine, quinoxaline, and imidazole can be synthesized from 1,2-diketones. It is also used as a nanocatalyst in the application of imidazole derivatives. Recently, it is reported that benzil derivatives acted as photosensitive agents and photoinitiators due to its antitumor activity[1].

Synthesis Reference(s)

Journal of the American Chemical Society, 105, p. 7755, 1983 DOI: 10.1021/ja00364a054
Tetrahedron Letters, 30, p. 6267, 1989 DOI: 10.1016/S0040-4039(01)93869-9

Safety

Potential Acute Health Effects: Very hazardous in case of skin contact (irritant), of eye contact (irritant). Hazardous in case of ingestion, of inhalation.
The substance is toxic to lungs, mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage. Eye Contact: Check for and remove any contact lenses.
Fine dust dispersed in air may ignite. Dust can form an explosive mixture in air. Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition.

Safety Profile

Low toxicity by ingestion. An eyeirritant. Combustible. When heated to decomposition itemits acrid smoke and irritating fumes.

Solubility in organics

Soluble in ethanol (50 mg/ml), chloroform, ether, and ethyl acetate. Insoluble in water.

Purification Methods

Crystallise benzil from *benzene after washing with alkali. (Crystallisation from EtOH did not free benzil from material reacting with alkali.) [Hine & Howarth J Am Chem Soc 80 2274 1958.] It has also been crystallised from CCl4, diethyl ether or EtOH [Inoue et al. J Chem Soc, Faraday Trans 1 82 523 1986]. [Beilstein 7 IV 2502.]

References

[1] N. Kanagathara. “Structural and Vibrational Investigation of Benzil-(1,2-Diphenylethane-1,2-Dione): Experimental and Theoretical Studies.” New Journal of Chemistry 3 1 (2022).

Properties of Benzil

Melting point: 94-95 °C(lit.)
Boiling point: 346 °C
Density  1,521 g/cm3
vapor pressure  1 mm Hg ( 128.4 °C)
refractive index  1.5681 (estimate)
Flash point: 346-348°C
storage temp.  Store below +30°C.
solubility  <0.5g/l
form  Crystalline Powder
color  White
Water Solubility  0.5 g/L (20 ºC)
Merck  14,1078
BRN  608047
Dielectric constant 13.0(94℃)
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference 134-81-6(CAS DataBase Reference)
NIST Chemistry Reference Ethanedione, diphenyl-(134-81-6)
EPA Substance Registry System Benzil (134-81-6)

Safety information for Benzil

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Benzil

InChIKey WURBFLDFSFBTLW-UHFFFAOYSA-N

Benzil manufacturer

Macleods Pharmaceuticals Limited

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Phone:+912266762800
product: Benzil 98%
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Orgamine Chemicals(I) Pvt Ltd

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Phone:+91-2512871746
product: Benzil 134-81-6 98%
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Navone Specialties (OPC) Pvt Ltd

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Phone:+91-9323789882
Whatsapp: +91- 9323789882
product: 134-81-6 99%
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ARRAKIS INDUSTRIES LLP

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Phone:+91-7499586750
Whatsapp: +91- 7499586750
product: BENZIL 134-81-6 99%
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Anand Agencies

Maharashtra
Phone:91-9075014125
Whatsapp: 91-9075014125
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Techno Pharmchem

Delhi
Phone:91-9818265860
Whatsapp: 91-9818265860
product: Benzil
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ALPHA CHEMIKA

Mumbai
Phone:91-9820385757
Whatsapp: 91-9820385757
product: Benzil
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G C Int'L

Maharashtra
Phone:91-7710026702
Whatsapp: 91-7710026702
product: Benzil
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Hildose

Maharashtra
product: Benzil
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