23-HYDROXYBETULINIC ACID
- CAS NO.：85999-40-2
- Empirical Formula: C30H48O4
- Molecular Weight: 472.7
- MDL number: MFCD28126999
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 23-HYDROXYBETULINIC ACID?
Description
23-hydroxy Betulinic acid is a triterpenoid that has been found in P. chinensis and has anticancer activity. It inhibits proliferation of K562, B16, and HeLa cells (IC50s = 39.9, 78.5, and 80 μM, respectively), as well as human umbilical vein endothelial cells (HUVECs; IC50 = 94.8 μM). It halts the cell cycle at the S phase and induces apoptosis in K562 cells in a concentration-dependent manner with a loss of the mitochondrial membrane potential and an increase in Bax and cytochrome C protein levels.
The Uses of 23-HYDROXYBETULINIC ACID
23-Hydroxybetulinic Acid is a potential cytoxic agent in the treatment of cancer. Apoptotic effect. Antiproliferative.
Definition
ChEBI: 23-Hydroxybetulinic acid is a triterpenoid. It has a role as a metabolite. It derives from a hydride of a lupane.
Properties of 23-HYDROXYBETULINIC ACID
| Melting point: | >293°C (dec.) |
| Boiling point: | 585.8±25.0 °C(Predicted) |
| Density | 1.106 |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Methanol (Slightly, Heated), Pyridine (Slightly) |
| form | Solid |
| pka | 4.60±0.70(Predicted) |
| color | White |
Safety information for 23-HYDROXYBETULINIC ACID
Computed Descriptors for 23-HYDROXYBETULINIC ACID
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