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HomeProduct name listCarboxyatractyloside

Carboxyatractyloside

Carboxyatractyloside Structural

What is Carboxyatractyloside?

The Uses of Carboxyatractyloside

Carboxyatractyloside potassium salt has been used as an activator of Ca2+-induced mPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) opening. It has also been used as a adenine nucleotide translocator (ANT) inhibitor to study the inhibition of oxidative phosphorylation in intact T98G glioma cells.

Biochem/physiol Actions

Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier; i.e. adenine nucleotide translocase (ANT); causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and apoptosis.

Properties of Carboxyatractyloside

Density  1.58±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  H2O: ≥10mg/mL
pka -3?+-.0.18(Predicted)
form  solid
color  white

Safety information for Carboxyatractyloside

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for Carboxyatractyloside

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