2,3-Dimethylmaleic anhydride

Synonym(s):2,3-Dimethylmaleic anhydride;3,4-Dimethyl-2,5-furandione;Dimethylmaleic anhydride

CAS NO.：766-39-2
Empirical Formula: C6H6O3
Molecular Weight: 126.11
MDL number: MFCD00005523
EINECS: 212-165-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 18:01:17

What is 2,3-Dimethylmaleic anhydride?

Chemical properties

white to beige crystals or cryst. powder

The Uses of 2,3-Dimethylmaleic anhydride

2,3-Dimethylmaleic anhydride can be usually used in the synthesis of maleimides and as an amino group protecting agent for superoxide dismutase. It is also used in the preparation of dimethylmaleic acid dimethyl ester. Further, it serves as a reactant in the dissociation of ribosomal proteins. In addition to this, The isolated molecule 2, 3-dimethylmaleic anhydride showed potent insecticidal activity in fumigation bioassay against several insect species, viz., adults of houseflies, cockroaches and stored-product insects.

Definition

ChEBI: 2,3-Dimethylmaleic anhydride is a butenolide. It is a 5-membered cyclic anhydride with a double bond between carbon atoms C2 and C3. The double bond locks the molecule in a planar conformation and stabilizes the acid anhydride against hydration. It was used as linker to a cell penetrating peptidebased nanoparticle.

Safety Profile

Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. See also ANHYDRIDES.

Purification Methods

Distil the anhydride from *benzene/ligroin and sublime in a vacuum. [Beilstein 17/11 V 69.]

Properties of 2,3-Dimethylmaleic anhydride

Melting point:	93-96 °C (lit.)
Boiling point:	223 °C (lit.)
Density	1.107 g/cm3 (100℃)
refractive index	1.5627 (estimate)
Flash point:	222-223°C
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Solid
color	White to Off-White
Water Solubility	Soluble in ethanol, ether and chloroform. Slightly soluble in water.
Sensitive	Moisture Sensitive
BRN	112044
CAS DataBase Reference	766-39-2(CAS DataBase Reference)
NIST Chemistry Reference	2,5-Furandione, 3,4-dimethyl-(766-39-2)
EPA Substance Registry System	2,5-Furandione, 3,4-dimethyl- (766-39-2)

Safety information for 2,3-Dimethylmaleic anhydride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..…