5,6,7,8-Tetrahydroquinoline
- CAS NO.:10500-57-9
- Empirical Formula: C9H11N
- Molecular Weight: 133.19
- MDL number: MFCD00006734
- EINECS: 234-030-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-20 19:26:33
What is 5,6,7,8-Tetrahydroquinoline ?
Chemical properties
Colorless to light yellow liquid
The Uses of 5,6,7,8-Tetrahydroquinoline
5,6,7,8-Tetrahydroquinoline can be used to prevent and treat of hyperlipemia.
Synthesis
5,6,7,8-Tetrahydroquinoline is prepared by the reaction of pyridine and 1,4-dichlorobutane. The specific synthesis steps are as follows:
At 25℃ and an inert atmosphere,Compound 2 (2.67 g, 21.02 mmol) was added to a suspension of aluminum chloride (0.20 g, 1.5 mmol) in pyridine (10 mL). After stirring the obtained orange solution for 24 hours, It was poured into an ice water mixture (50 g) and extracted with ethyl acetate (50 mL).The organic layer was separated and washed sequentially with water (50 mL). The organic layer was washed with saturated sodium bicarbonate solution (50 mL) and brine (50 mL). It was then dried over NaSO4 and concentrated in vacuo. The yellow oil was subjected to flash chromatography on silica gel (eluent: hexane), Obtaining 5,6,7,8-tetrahydroquinoline, 2.66 g, yield 95%.
Properties of 5,6,7,8-Tetrahydroquinoline
Boiling point: | 238°C |
Density | 1,08 g/cm3 |
refractive index | 1.5420 to 1.5450 |
Flash point: | 90°C |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Sparingly) Methanol (Slightly) |
form | Oil |
pka | 6.30±0.20(Predicted) |
Specific Gravity | 1.0341.0304 (20/4℃) |
color | Colourless |
InChI | InChI=1S/C9H11N/c1-2-6-9-8(4-1)5-3-7-10-9/h3,5,7H,1-2,4,6H2 |
CAS DataBase Reference | 10500-57-9(CAS DataBase Reference) |
NIST Chemistry Reference | Quinoline, 5,6,7,8-tetrahydro-(10500-57-9) |
Safety information for 5,6,7,8-Tetrahydroquinoline
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 5,6,7,8-Tetrahydroquinoline
InChIKey | YQDGQEKUTLYWJU-UHFFFAOYSA-N |
SMILES | N1C2=C(CCCC2)C=CC=1 |
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