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HomeProduct name list5,6,7,8-Tetrahydroquinoline

5,6,7,8-Tetrahydroquinoline

  • CAS NO.:10500-57-9
  • Empirical Formula: C9H11N
  • Molecular Weight: 133.19
  • MDL number: MFCD00006734
  • EINECS: 234-030-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-03-20 19:26:33
5,6,7,8-Tetrahydroquinoline  Structural

What is 5,6,7,8-Tetrahydroquinoline ?

Chemical properties

Colorless to light yellow liquid

The Uses of 5,6,7,8-Tetrahydroquinoline

5,6,7,8-Tetrahydroquinoline can be used to prevent and treat of hyperlipemia.

Synthesis

5,6,7,8-Tetrahydroquinoline is prepared by the reaction of pyridine and 1,4-dichlorobutane. The specific synthesis steps are as follows:
At 25℃ and an inert atmosphere,Compound 2 (2.67 g, 21.02 mmol) was added to a suspension of aluminum chloride (0.20 g, 1.5 mmol) in pyridine (10 mL). After stirring the obtained orange solution for 24 hours, It was poured into an ice water mixture (50 g) and extracted with ethyl acetate (50 mL).The organic layer was separated and washed sequentially with water (50 mL). The organic layer was washed with saturated sodium bicarbonate solution (50 mL) and brine (50 mL). It was then dried over NaSO4 and concentrated in vacuo. The yellow oil was subjected to flash chromatography on silica gel (eluent: hexane), Obtaining 5,6,7,8-tetrahydroquinoline, 2.66 g, yield 95%.
5,6,7,8-Tetrahydroquinoline synthesis

Properties of 5,6,7,8-Tetrahydroquinoline

Boiling point: 238°C
Density  1,08 g/cm3
refractive index  1.5420 to 1.5450
Flash point: 90°C
storage temp.  Inert atmosphere,Room Temperature
solubility  Chloroform (Slightly), DMSO (Sparingly) Methanol (Slightly)
form  Oil
pka 6.30±0.20(Predicted)
Specific Gravity 1.0341.0304 (20/4℃)
color  Colourless
InChI InChI=1S/C9H11N/c1-2-6-9-8(4-1)5-3-7-10-9/h3,5,7H,1-2,4,6H2
CAS DataBase Reference 10500-57-9(CAS DataBase Reference)
NIST Chemistry Reference Quinoline, 5,6,7,8-tetrahydro-(10500-57-9)

Safety information for 5,6,7,8-Tetrahydroquinoline

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for 5,6,7,8-Tetrahydroquinoline

InChIKey YQDGQEKUTLYWJU-UHFFFAOYSA-N
SMILES N1C2=C(CCCC2)C=CC=1

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