2-Pyridylethylamine
Synonym(s):2-(2-Aminoethyl)pyridine
- CAS NO.：2706-56-1
- Empirical Formula: C7H10N2
- Molecular Weight: 122.17
- MDL number: MFCD00006367
- EINECS: 220-295-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 14:53:31
What is 2-Pyridylethylamine?
Chemical properties
clear colorless to yellow liquid
The Uses of 2-Pyridylethylamine
2-(2-Aminoethyl)pyridine is used as active pharmaceutical ingredients.
Definition
ChEBI: An aminoalkylpyridine that is pyridine substituted by a ethanamino group at position 2.
Biological Activity
Low doses of histamine or H1R agonist 2-pyridylethylamine (2-PEA) into the knee-joint were found to decrease formalin-induced articular nociception in rats. The pharmacological blockade and neurotoxic ablation of cells expressing neuropeptide Y1 receptor (Y1R) in the spinal cord were able to prevent the antinociceptive effect produced by the intra-articular administration of the histamine H1 receptor (H1R) agonist, 2-pyridylethilamine (2-PEA), in the formalin-induced articular incapacitation in rats[1].
References
[1] Eduardo Souza-Silva. “Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model.” Brain Research 1735 (2020): Article 146757.
Properties of 2-Pyridylethylamine
| Melting point: | 198-200 °C(Solv: ethanol (64-17-5)) |
| Boiling point: | 92-93 °C12 mm Hg(lit.) |
| Density | 1.021 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 213 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | Liquid |
| pka | pK1: 4.24(+2);pK2: 9.78(+1) (25°C,μ=0.05) |
| Specific Gravity | 1.021 |
| color | Clear colorless to yellow |
| Water Solubility | Soluble in water (partly), and most common polar solvent. Insoluble in non-polar solvents, and oils. |
| Sensitive | Air Sensitive |
| BRN | 111208 |
| CAS DataBase Reference | 2706-56-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Pyridineethanamine(2706-56-1) |
| EPA Substance Registry System | 2-Pyridineethanamine (2706-56-1) |
Safety information for 2-Pyridylethylamine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Pyridylethylamine
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