2-Pyridinol-1-oxide

Synonym(s):1-Hydroxy-2-pyridone;2-Hydroxypyridine 1-oxide;HOPO

CAS NO.：13161-30-3
Empirical Formula: C5H5NO2
Molecular Weight: 111.1
MDL number: MFCD00006195
EINECS: 236-100-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-25 23:13:37

What is 2-Pyridinol-1-oxide?

Chemical properties

Weight 20% solution in water

The Uses of 2-Pyridinol-1-oxide

2-Pyridinol 1-oxide can be used:????

To fabricate gold electrodes for the electrochemical determination of europium using cyclic voltammetry.????????
To prepare polymeric nickel (II) complex of 2-hydroxypyridine-N-oxide.
In the synthesis of 1-methoxypyrid-4-one in the presence of sodium methoxide and methyl toluene-9-sulphonate.

What are the applications of Application

2-Pyridinol 1-oxide is A peptide coupling agent

Definition

Bactericidal agent related to aspergillic acid, made from pyridine-N-oxide.

General Description

2-Pyridinol 1-oxide (HOPO) is a peptide coupling agent used as a subsititue for HOBt. It can form stable chelate complexes with transition metal ions.

Properties of 2-Pyridinol-1-oxide

Melting point:	147-152 °C
Boiling point:	387.7±15.0 °C(Predicted)
Density	1.111
vapor pressure	0.223Pa at 25℃
Flash point:	100 °C
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	pK1:-0.62;pK2:5.97(0) (25°C)
color	Off-White to Light Yellow
Water Solubility	331g/L
BRN	1422545
CAS DataBase Reference	13161-30-3(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridinol-1-oxide(13161-30-3)

Safety information for 2-Pyridinol-1-oxide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.