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HomeProduct name list2-Nitrobenzyl bromide

2-Nitrobenzyl bromide

Synonym(s):α-Bromo-2-nitrotoluene

  • CAS NO.:3958-60-9
  • Empirical Formula: C7H6BrNO2
  • Molecular Weight: 216.03
  • MDL number: MFCD00007184
  • EINECS: 223-558-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
2-Nitrobenzyl bromide Structural

What is 2-Nitrobenzyl bromide?

Chemical properties

white to light yellow crystal powde

The Uses of 2-Nitrobenzyl bromide

2-Nitrobenzyl bromide is used in the preparation of S-2-nitrobenzyl-cysteine by reaction with L-cysteine. It is also used for the introduction of the 2-nitrobenzyl protecting group in organic synthesis. It plays an important role in the production of expectorant agent. Further, it is employed for caging unprotected cysteine-containing or thiophosphorylated peptides in aqueous solution. In addition to this, it is used in the preparation of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one.

The Uses of 2-Nitrobenzyl bromide

2-Nitrobenzyl bromide was used for caging unprotected cysteine-containing or thiophosphorylated peptides in aqueous solution. It can be used in the synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one.

What are the applications of Application

2-Nitrobenzyl bromide is a reagent used for caging unprotected cysteine and thiophosphoryl peptides in aqueous solution

Biochem/physiol Actions

2-Nitrobenzyl bromide reacts with L-cysteine to form S-2-nitrobenzyl-cysteine which was used for modification of ultra-low-gelling-temperature (ULGT) agarose.

Properties of 2-Nitrobenzyl bromide

Melting point: 44-46 °C (lit.)
Boiling point: 265.51°C (rough estimate)
Density  1.6841 (rough estimate)
refractive index  1.6120 (estimate)
Flash point: >230 °F
storage temp.  Inert atmosphere,2-8°C
solubility  Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form  Crystals or Crystalline Powder
color  Yellow to light brown
Water Solubility  insoluble
BRN  638991
Stability: Hygroscopic
CAS DataBase Reference 3958-60-9(CAS DataBase Reference)
NIST Chemistry Reference 2-Nitrobenzyl bromide(3958-60-9)

Safety information for 2-Nitrobenzyl bromide

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H314:Skin corrosion/irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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