4,5-DIMETHOXY-2-NITROBENZYL BROMIDE

Synonym(s):6-Nitroveratryl bromide

CAS NO.：53413-67-5
Empirical Formula: C9H10BrNO4
Molecular Weight: 276.08
MDL number: MFCD00192064
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

4,5-DIMETHOXY-2-NITROBENZYL BROMIDE Structural

What is 4,5-DIMETHOXY-2-NITROBENZYL BROMIDE?

The Uses of 4,5-DIMETHOXY-2-NITROBENZYL BROMIDE

4,5-Dimethoxy-2-nitrobenzyl bromide (DMNB bromide, 6-nitroveratryl bromide) is suitable reagent used in the synthesis of N-(4,5-dimethoxy-2-nitrobenzyl)vanillylamine which forms caged vanilloid. It may be used in the synthesis of the following:

4-(4′,5′-dimethoxy-2-nitrobenzyloxy)benzaldehyde, a DMNB-caged aldehyde
N-[4-[(4,5-dimethoxy-2-nitrobenzyl)oxy]-3-methoxybenzyl]acetamide
caged derivative of pyridostatin ([C]-PDS)
photosensitive polyimide (PI-DMNB)
caged β-ecdysone
4-tert-butyldimethylsilyloxy-1-(2-deoxy-3,5-di-O-toluoyl-β-D-ribofuranosyl)-2-(6-nitroveratrylthio)-1H-benzimidazole, an intermediate in synthesis of phosphoramidite bearing 4-hydroxy-2-mercaptobenzimidazole (SB^NV) nucleobase
alkylation of dihydrofluorescein
4-(4′,5′-Dimethoxy-2′-nitrobenzyloxy)benzaldehyde

The Uses of 4,5-DIMETHOXY-2-NITROBENZYL BROMIDE

1-(Bromomethyl)-4,5-dimethoxy-2-nitrobenzene is a useful research chemical.

General Description

4,5-Dimethoxy-2-nitrobenzyl bromide (DMNBB, 1-(Bromomethyl)-4,5-dimethoxy-2-nitrobenzene) is a 4,5-dimethoxy-2-nitrobenzyl derivative. 4,5-Dimethoxy-2-nitrobenzyl (DMNB) group of DMNBB is used as a photolabile protecting group in caging technology to develop pro-drugs. Synthesis of 1-(bromomethyl)-4,5-dimethoxy-2-nitrobenzene by using 6-nitroveratraldehyde as starting reagent has been reported.

Properties of 4,5-DIMETHOXY-2-NITROBENZYL BROMIDE

Melting point:	131-133 °C (lit.)
Boiling point:	372.3±37.0 °C(Predicted)
Density	1.544
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Crystalline Powder or Needles
color	Yellow to brown
Sensitive	Lachrymatory

Safety information for 4,5-DIMETHOXY-2-NITROBENZYL BROMIDE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.