2-Naphthoic acid
Synonym(s):2-Naphthalenecarboxylic acid
- CAS NO.:93-09-4
- Empirical Formula: C11H8O2
- Molecular Weight: 172.18
- MDL number: MFCD00004101
- EINECS: 202-217-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-22 16:39:17
What is 2-Naphthoic acid?
Chemical properties
Colorless solid
The Uses of 2-Naphthoic acid
2-Naphthoic acid is an unprotected acid undergoes lithiation, e.g. with s-BuLi, by stereospecific 1,4-addition, providing a facile route to 1,2,2-trisubstituted 1,2-dihydronaphthalenes. It is also used as an intermediate in organic synthesis. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.
Definition
ChEBI: 2-naphthoic acid is a naphthoic acid that is naphthalene carrying a carboxy group at position 2. It has a role as a xenobiotic metabolite and a mouse metabolite. It is a conjugate acid of a 2-naphthoate.
General Description
2-Naphthoic acid (NPA) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor inhibitor. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.
Purification Methods
Crystallise the acid from EtOH (4mL/g), aqueous 50% EtOH or Me2CO (m 185-186o). Dry it at 100o. The acid chloride has m 52-52o (from *C6H6/pet ether) and b 160-162o/11mm [Hersberg & Carson Org Synth Coll Vol III 629 1955], the amide has m 192o (from EtOH), and the N-Methyl amide has m 109-109.5o (form *C6H6). [Beilstein 9 H 656, 9 III 3174, 9 IV 2402.]
Properties of 2-Naphthoic acid
Melting point: | 185-187 °C(lit.) |
Boiling point: | 300 °C |
Density | 1.08 |
refractive index | 1.5520 (estimate) |
Flash point: | 205 °C |
storage temp. | Sealed in dry,Room Temperature |
solubility | alcohol: soluble |
pka | 4.17(at 25℃) |
form | Powder |
color | White to beige |
PH | 4.5 (H2O, 20℃) |
Water Solubility | <0.5 g/L (20 C) |
Merck | 14,6382 |
BRN | 972039 |
CAS DataBase Reference | 93-09-4(CAS DataBase Reference) |
NIST Chemistry Reference | 2-Naphthalenecarboxylic acid(93-09-4) |
EPA Substance Registry System | 2-Naphthalenecarboxylic acid (93-09-4) |
Safety information for 2-Naphthoic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Naphthoic acid
InChIKey | UOBYKYZJUGYBDK-UHFFFAOYSA-N |
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