2-Methoxy-3-isobutyl pyrazine

CAS NO.：24683-00-9
Empirical Formula: C9H14N2O
Molecular Weight: 166.22
MDL number: MFCD00006128
EINECS: 246-402-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is 2-Methoxy-3-isobutyl pyrazine?

Description

2-Isobutyl-3-methoxypyrazine has an extremely powerful odor with a reported threshold value of 2 parts per trillion in water. Diluted water solutions exhibit a characteristic odor of green bell peppers. May be synthesized by condensation of leucine amide with glyoxal, followed by methylation with CH2H2.

Chemical properties

CLEAR COLOURLESS LIQUID

Chemical properties

2-Isobutyl-3-methoxypyrazine has a green bell pepper, green pea odor. Diluted water solutions of this compound exhibit a characteristic odor of green bell peppers.

Occurrence

Reported present in green bell pepper, coffee, galbanum oil, potato products, peas, grapes, lettuce, sherry, white wine, cocoa, beans, beetroot, passion fruit and okra.

The Uses of 2-Methoxy-3-isobutyl pyrazine

2-Isobutyl-3-methoxypyrazine has been employed as a model odorant molecule during an electrochemical assay for the detection of odorant molecules based on a rat odorant-binding protein (rOBP3).

What are the applications of Application

2-Isobutyl-3-methoxypyrazine is a useful molecul for electrochemical assay for the detection of odorant molecules

Preparation

By condensation of leucine amide with glyoxal followed by methylation with CH2H2

Aroma threshold values

Detection: 2 ppt to 10 ppb

General Description

2-Isobutyl-3-methoxypyrazine, a potent bell-pepper odourant, has been found to bind to cow olfactory mucosa homogenate.

Properties of 2-Methoxy-3-isobutyl pyrazine

Boiling point:	294.44°C (rough estimate)
Density	0.99 g/mL at 25 °C(lit.)
refractive index	n20/D 1.49(lit.)
FEMA	3132 \| 2-ISOBUTYL-3-METHOXYPYRAZINE
Flash point:	176 °F
storage temp.	room temp
form	Liquid
pka	0.80±0.10(Predicted)
Specific Gravity	0.995
color	Clear colorless
Odor	green-pepper odor FCT 2000
JECFA Number	792
CAS DataBase Reference	24683-00-9(CAS DataBase Reference)
NIST Chemistry Reference	Pyrazine, 2-methoxy-3-(2-methylpropyl)-(24683-00-9)
EPA Substance Registry System	Pyrazine, 2-methoxy-3-(2-methylpropyl)- (24683-00-9)

Safety information for 2-Methoxy-3-isobutyl pyrazine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.