Pyrazine
Synonym(s):1,4-Diazine;Pyrazine
- CAS NO.:290-37-9
- Empirical Formula: C4H4N2
- Molecular Weight: 80.09
- MDL number: MFCD00006122
- EINECS: 206-027-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02

What is Pyrazine?
Chemical properties
white crystals or powder
Chemical properties
Pyrazine has a strong pyridine-like odor. Some reports compare the taste of pyrazine to cooked spinach or rancid peanuts
Occurrence
Pyrazine has been detected in several food products including papayas, asparagus, peanuts, popcorn, soybeans, corn, French fries, bread, cheese, milk, eggs (boiled), chicken (fried), beef (cooked), shrimp, clams, beer, sherry, malt, coffee and tea (green).
The Uses of Pyrazine
Pyrazine is used as a flavoring agent. It serves as a component of some herbs in traditional Chinese medicine. It is employed as pharmaceutical intermediates, perfume intermediates and involved in the preparation of other chemicals. In addition to this, it is used in the production of pyrazine 1-oxide.
Definition
ChEBI: A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.
Definition
A heterocyclic aromatic compound with a six-membered ring containing four carbon atoms and two nitrogen atoms.
Definition
pyrazine: An unsaturated heterocycliccompound having two nitrogenatoms in a six-membered ring,C4H4N2; r.d. 1.03; m.p. 52°C; b.p.115°C. Pyrazine is a symmetric diazine.
Preparation
Prepared by cyclization of α-amino ketones, which were produced by the reduction of isonitroso ketones to yield the dihydropyrazines, which are dehydrogenated with mercury(I) oxide or copper(II) sulfate or sometimes with atmospheric oxygen.
Aroma threshold values
300 ppm (odor threshold in water)
General Description
Pyrazine is a 1,4-diazine and an electron-deficient N-heteroarene found in several natural products, APIs, agrochemicals, and functional materials.
Purification Methods
Distil pyrazine in steam and crystallise it from water. Purify also by zone melting. [Beilstein 23 H 91, 23 II 80, 23 III/IV 899, 23/5 V 351.]
Properties of Pyrazine
Melting point: | 50-56 °C (lit.) |
Boiling point: | 115-116 °C (lit.) |
Density | 1.031 g/mL at 25 °C (lit.) |
refractive index | 1.5235 |
FEMA | 4015 | PYRAZINE |
Flash point: | 132 °F |
storage temp. | Store below +30°C. |
solubility | SOLUBLE |
form | Crystals |
pka | 0.65(at 27℃) |
color | White |
Specific Gravity | 1.031 |
Odor | at 0.10 % in propylene glycol. pungent sweet corn like roasted hazelnut barly |
Water Solubility | SOLUBLE |
Sensitive | Hygroscopic |
Merck | 14,7957 |
JECFA Number | 951 |
BRN | 103905 |
Dielectric constant | 2.7999999999999998 |
Stability: | Stable. Highly flammable. Incompatible with acids, oxidizing agents. |
CAS DataBase Reference | 290-37-9(CAS DataBase Reference) |
NIST Chemistry Reference | Pyrazine(290-37-9) |
EPA Substance Registry System | Pyrazine (290-37-9) |
Safety information for Pyrazine
Signal word | Danger |
Pictogram(s) |
![]() Flame Flammables GHS02 |
GHS Hazard Statements |
H228:Flammable solids |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction. |
Computed Descriptors for Pyrazine
Pyrazine manufacturer
Related products of tetrahydrofuran





![1-(2,5-DIMETHOXYPHENYL)-1,2,3,4-TETRAHYDROPYRROLO[1,2-A]PYRAZINE](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB3712632.gif)


You may like
-
Pyrazine, 98% 290-37-9 99%View Details
290-37-9 -
Pyrazine CAS 290-37-9View Details
290-37-9 -
Pyrazine CAS 290-37-9View Details
290-37-9 -
Pyrazine 99% CAS 290-37-9View Details
290-37-9 -
Pyrazine CAS 290-37-9View Details
290-37-9 -
Pyrazine CAS 290-37-9View Details
290-37-9 -
37951-47-6 3'-Benzyloxy propiophenone, 98% 99%View Details
37951-47-6 -
3'-Methoxypropiophenone, 99% 37951-49-8 99%View Details
37951-49-8