2-Hydrazino-4-(trifluoromethyl)pyrimidine

CAS NO.：197305-97-8
Empirical Formula: C5H5F3N4
Molecular Weight: 178.12
MDL number: MFCD00115112
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 2-Hydrazino-4-(trifluoromethyl)pyrimidine?

Chemical properties

White to light yellow solid

The Uses of 2-Hydrazino-4-(trifluoromethyl)pyrimidine

2-Hydrazino-4-(trifluoromethyl)pyrimidine may be used as a derivatization reagent for the simultaneous determination of testosterone (T) and dihydrotestosterone (DHT) in murine tissue and serum. Synthesis of organohydrazide chelate complexes of rhenium and technetium. Preparation of 1-(4-methoxyphenyl)ethanone [(4-trifluoromethyl)pyrimidine-2-yl]hydrazone (NAS-75).

The Uses of 2-Hydrazino-4-(trifluoromethyl)pyrimidine

2-Hydrazino-4-(trifluoromethyl)pyrimidine may be used in the following studies:

As derivatization reagent for the simultaneous determination of testosterone (T) and dihydrotestosterone (DHT) in murine tissue and serum samples by liquid chromatography-electrospray ionization-tandem mass spectrometry.
Synthesis of organohydrazide chelate complexes of rhenium and technetium, having a metal-nitrogen-nitrogen linkage.
Preparation of 1-(4-methoxyphenyl)ethanone [(4-trifluoromethyl)pyrimidine-2-yl]hydrazone (NAS-75).

Properties of 2-Hydrazino-4-(trifluoromethyl)pyrimidine

Melting point:	99-101 °C(lit.)
Boiling point:	187.4±50.0 °C(Predicted)
Density	1.62±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Soluble in aqueous acid.
form	powder to crystal
pka	5.63±0.40(Predicted)
color	White to Orange to Green

Safety information for 2-Hydrazino-4-(trifluoromethyl)pyrimidine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H302:Acute toxicity,oral H311:Acute toxicity,dermal H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.