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HomeProduct name list2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Synonym(s):Chloro(diisopropylamino)-β-cyanoethoxyphosphine

  • CAS NO.:89992-70-1
  • Empirical Formula: C9H18ClN2OP
  • Molecular Weight: 236.68
  • MDL number: MFCD00011544
  • EINECS: 628-591-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-04 20:40:58
2-Cyanoethyl N,N-diisopropylchlorophosphoramidite Structural

What is 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite?

Chemical properties

Slightly Hazy Yellow Liquid

The Uses of 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

A protecting reagent in DNA synthesis. Also a phosphorylating agent

The Uses of 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

2-Cyanoethyl diisopropylchlorophosphoramidite is a useful intermediate in organic synthesis. It acts as a protecting reagent in DNA synthesis. It is involved in the selective monophosphorylation of carbohydrates and nucleosides. It plays an essential role in the conversion of protected ribonucleosides to phosphoramidites. It is also utilized as phosphitylating reagent for 3'-hydroxyl groups in the synthesis of oligodeoxyribonucleotides.

Properties of 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Boiling point: 103-105°C 0,08mm
Density  1.061 g/mL at 25 °C(lit.)
refractive index  n20/D 1.479
Flash point: >230 °F
storage temp.  −20°C
solubility  Miscible with chloroform and dichloromethane.
form  Crystalline Powder
pka 0.83±0.70(Predicted)
color  clear to very slightly hazy colorless
Sensitive  Moisture Sensitive
BRN  3588525
Stability: Hygroscopic, Moisture Sensitive
InChI InChI=1S/C9H18ClN2OP/c1-8(2)12(9(3)4)14(10)13-7-5-6-11/h8-9H,5,7H2,1-4H3
CAS DataBase Reference 89992-70-1(CAS DataBase Reference)

Safety information for 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H250:Pyrophoric liquids; Pyrorophoric solids
H314:Skin corrosion/irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P334:IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378:In case of fire: Use … for extinction.

Computed Descriptors for 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

InChIKey QWTBDIBOOIAZEF-UHFFFAOYSA-N
SMILES P(N(C(C)C)C(C)C)(Cl)OCCC#N

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