2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
Synonym(s):Chloro(diisopropylamino)-β-cyanoethoxyphosphine
- CAS NO.：89992-70-1
- Empirical Formula: C9H18ClN2OP
- Molecular Weight: 236.68
- MDL number: MFCD00011544
- EINECS: 628-591-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-11 17:04:31
What is 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite?
Chemical properties
Slightly Hazy Yellow Liquid
The Uses of 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
A protecting reagent in DNA synthesis. Also a phosphorylating agent
The Uses of 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
2-Cyanoethyl diisopropylchlorophosphoramidite is a useful intermediate in organic synthesis. It acts as a protecting reagent in DNA synthesis. It is involved in the selective monophosphorylation of carbohydrates and nucleosides. It plays an essential role in the conversion of protected ribonucleosides to phosphoramidites. It is also utilized as phosphitylating reagent for 3'-hydroxyl groups in the synthesis of oligodeoxyribonucleotides.
Properties of 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
| Boiling point: | 103-105°C 0,08mm |
| Density | 1.061 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | −20°C |
| solubility | Miscible with chloroform and dichloromethane. |
| form | Crystalline Powder |
| pka | 0.83±0.70(Predicted) |
| color | clear to very slightly hazy colorless |
| Sensitive | Moisture Sensitive |
| BRN | 3588525 |
| Stability: | Hygroscopic, Moisture Sensitive |
| InChI | InChI=1S/C9H18ClN2OP/c1-8(2)12(9(3)4)14(10)13-7-5-6-11/h8-9H,5,7H2,1-4H3 |
| CAS DataBase Reference | 89992-70-1(CAS DataBase Reference) |
Safety information for 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H250:Pyrophoric liquids; Pyrorophoric solids H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P334:IF ON SKIN: Immerse in cool water/wrap in wet bandages. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. |
Computed Descriptors for 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
| InChIKey | QWTBDIBOOIAZEF-UHFFFAOYSA-N |
| SMILES | P(N(C(C)C)C(C)C)(Cl)OCCC#N |
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