2-(chloromethyl)-4-methylquinazoline
- CAS NO.:109113-72-6
- Empirical Formula: C10H9ClN2
- Molecular Weight: 192.64
- MDL number: MFCD09807547
- EINECS: 476-280-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-19 17:35:41
What is 2-(chloromethyl)-4-methylquinazoline?
Chemical properties
White to yellow powder
The Uses of 2-(chloromethyl)-4-methylquinazoline
2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.
Synthesis
Into a 500ml reaction flask, add o-aminoacetophenone, chloroacetonitrile, 1,4-dioxane, and N-methyl-3(3-sulfopropyl)imidazolium hydrogen sulfate prepared above. Stir to dissolve, cool the reaction system to 8°C, and dropwise add hydrochloric acid to the reaction system. The reaction temperature was kept unchanged during the dropwise addition. After that, the reaction was continued at 8°C for 18 hours to complete the reaction process. After the reaction, ammonia water (the concentration of ammonia water was 10wt%) at 5°C was added to the reaction system. After stirring and crystallizing at 5 for 30 minutes, filter to obtain a filter cake, washing the filter cake with water. Recrystallized with 200ml of dichloromethane to obtain 2-(chloromethyl)-4-methylquinazoline. yield: 85.14%
Properties of 2-(chloromethyl)-4-methylquinazoline
Melting point: | 61.0 to 65.0 °C |
Boiling point: | 240.0±32.0 °C(Predicted) |
Density | 1.251 |
vapor pressure | 0Pa at 20℃ |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
pka | 1.86±0.50(Predicted) |
form | powder to crystal |
color | Light yellow to Yellow to Orange |
Water Solubility | 3.11g/L at 20℃ |
λmax | 318nm(EtOH)(lit.) |
Safety information for 2-(chloromethyl)-4-methylquinazoline
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-(chloromethyl)-4-methylquinazoline
InChIKey | UHCUBOJGMLASBY-UHFFFAOYSA-N |
Abamectin manufacturer
VGS SYNTHESIS PRIVATE LIMITED
Sris Synthesis Pvt Ltd.,
Bulat Pharmaceutical Pvt Ltd
WARUKSHA LABORATORIES PVT LTD
JSK Chemicals
Synaptics Labs Private Limited
Darsh PharmaChem Pvt Ltd
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2-(Chloromethyl)-4-methylquinazoline CAS 109113-72-6View Details
109113-72-6