2-Chloro-4-picoline
Synonym(s):2-Chloro-4-picoline
- CAS NO.：3678-62-4
- Empirical Formula: C6H6ClN
- Molecular Weight: 127.57
- MDL number: MFCD00023418
- EINECS: 222-951-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-11 15:28:25
What is 2-Chloro-4-picoline?
Chemical properties
Colorless to light yellow liquid.
The Uses of 2-Chloro-4-picoline
2-Chloro-4-methylpyridine is used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines as potential antipsychotics. It is also used in the preparation of trifluoromethyl(pyrimidinyl)azetidinecarboxamides as potent, orally bioavailable TGR5 agonists.
What are the applications of Application
2-Chloro-4-methylpyridine is a halogenated heterocycle used in synthesis
General Description
2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.
Properties of 2-Chloro-4-picoline
| Melting point: | 115°C |
| Boiling point: | 194-195 °C (lit.) |
| Density | 1.142 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 193 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Liquid |
| pka | 0.94±0.10(Predicted) |
| Specific Gravity | 1.14 |
| color | Clear colorless to light yellow |
| InChI | InChI=1S/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3 |
| CAS DataBase Reference | 3678-62-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Cl-4-(CH3)-pyridine(3678-62-4) |
Safety information for 2-Chloro-4-picoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Chloro-4-picoline
| InChIKey | MZVSTDHRRYQFGI-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC(C)=C1 |
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