2'-C-Methylcytidine
Synonym(s):2′-C-Methyl Cytidine;NM107
- CAS NO.:20724-73-6
- Empirical Formula: C10H15N3O5
- Molecular Weight: 257.24
- MDL number: MFCD02682947
- EINECS: 200-001-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is 2'-C-Methylcytidine?
Description
2''-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity. It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human coronavirus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM). In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.
Chemical properties
White to Off-White Powder
The Uses of 2'-C-Methylcytidine
2’-C-Methyl Cytidine (cas# 20724-73-6) is a compound useful in organic synthesis.
What are the applications of Application
2′-C-Methyl Cytidine is potent inhibitor of the HCV NS5B RNA polymerase
Biochem/physiol Actions
2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.
Properties of 2'-C-Methylcytidine
Melting point: | 243-245°C |
Boiling point: | 523.9±60.0 °C(Predicted) |
Density | 1.72±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | H2O: >20mg/mL |
form | powder |
pka | 13.53±0.70(Predicted) |
color | white to off-white |
Safety information for 2'-C-Methylcytidine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2'-C-Methylcytidine
InChIKey | PPUDLEUZKVJXSZ-VPCXQMTMSA-N |
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