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HomeProduct name list2'-C-Methylcytidine

2'-C-Methylcytidine

Synonym(s):2′-C-Methyl Cytidine;NM107

  • CAS NO.:20724-73-6
  • Empirical Formula: C10H15N3O5
  • Molecular Weight: 257.24
  • MDL number: MFCD02682947
  • EINECS: 200-001-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
2'-C-Methylcytidine Structural

What is 2'-C-Methylcytidine?

Description

2''-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity. It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human coronavirus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM). In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.

Chemical properties

White to Off-White Powder

The Uses of 2'-C-Methylcytidine

2’-C-Methyl Cytidine (cas# 20724-73-6) is a compound useful in organic synthesis.

What are the applications of Application

2′-C-Methyl Cytidine is potent inhibitor of the HCV NS5B RNA polymerase

Biochem/physiol Actions

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.

Properties of 2'-C-Methylcytidine

Melting point: 243-245°C
Boiling point: 523.9±60.0 °C(Predicted)
Density  1.72±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  H2O: >20mg/mL
form  powder
pka 13.53±0.70(Predicted)
color  white to off-white

Safety information for 2'-C-Methylcytidine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2'-C-Methylcytidine

InChIKey PPUDLEUZKVJXSZ-VPCXQMTMSA-N

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