2-Benzyloxyethanol

Synonym(s):Ethylene glycol monobenzyl ether

CAS NO.：622-08-2
Empirical Formula: C9H12O2
Molecular Weight: 152.19
MDL number: MFCD00002868
EINECS: 210-719-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:07:02

What is 2-Benzyloxyethanol?

Description

Benzyl-PEG2-alcohol is a PEG linker with an acid labile, benzyl protecting group and a reactive primary alcohol. The primary alcohol can react and further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Chemical properties

Ethylene glycol monobenzyl ether is a Colorless to light yellow liquid which will dissolve a large number of organic substances among which are oils, fats, greases, some vinyl resins, dewaxed damar, rosin, ester gum, etc. It is used principally as a high boiling solvent in lacquers, inks, and textile dyeing.

The Uses of 2-Benzyloxyethanol

2-Benzyloxyethanol is used in a base-free iridium-catalyzed direct alkylation of active methylene compounds with alcohols.

The Uses of 2-Benzyloxyethanol

2-(Benzyloxy)ethanol has been used in:

9-(2-hydroxyethyl)-linked synthesis of 2,6-diaminopurines
synthesis of benzyloxy ethyl methacrylate monomer by esterification with methacryloyl chloride
a base-free iridium-catalyzed direct alkylation of active methylene compounds with alcohols

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 389, 1990 DOI: 10.1016/S0040-4039(00)94562-3

Hazard

Toxic by ingestion.

Properties of 2-Benzyloxyethanol

Melting point:	<-75 °C
Boiling point:	265 °C (lit.)
Density	1.071 g/mL at 25 °C (lit.)
vapor pressure	7.3hPa at 25℃
refractive index	n20/D 1.521(lit.)
Flash point:	110 °C
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	14.40±0.10(Predicted)
form	Liquid
color	Clear colorless
Specific Gravity	1.07
Odor	mild rose
Water Solubility	4.282g/L(23 ºC)
BRN	2043566
CAS DataBase Reference	622-08-2(CAS DataBase Reference)
NIST Chemistry Reference	Ethanol, 2-(phenylmethoxy)-(622-08-2)
EPA Substance Registry System	Ethanol, 2-(phenylmethoxy)- (622-08-2)

Safety information for 2-Benzyloxyethanol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.