2-Aminothiazole
Synonym(s):2-Aminothiazole;2-Thiazolamine;2-Thiazolylamine
- CAS NO.：96-50-4
- Empirical Formula: C3H4N2S
- Molecular Weight: 100.14
- MDL number: MFCD00005325
- EINECS: 202-511-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is 2-Aminothiazole ?
Chemical properties
brown crystalline powder, grains, lumps or flakes
The Uses of 2-Aminothiazole
2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds.
The Uses of 2-Aminothiazole
antithyroid agent
The Uses of 2-Aminothiazole
Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation.
Definition
ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 693, 1954 DOI: 10.1021/ja01632a016
General Description
Light brown crystals or brown granular solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
2-Aminothiazole reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-Aminothiazole is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides.
Fire Hazard
Flash point data for 2-Aminothiazole are not available; however, 2-Aminothiazole is probably combustible.
Biochem/physiol Actions
2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders.
Safety Profile
Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi
Purification Methods
It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.]
Properties of 2-Aminothiazole
| Melting point: | 91-93 °C (lit.) |
| Boiling point: | 117 °C (15.002 mmHg) |
| Density | 1.241 (estimate) |
| vapor pressure | <1 hPa (20 °C) |
| refractive index | 1.5300 (estimate) |
| Flash point: | 117°C/15mm |
| storage temp. | Store below +30°C. |
| solubility | 1 M HCl: soluble50mg/mL, clear (dark yellow-brown) |
| pka | 5.36(at 20℃) |
| form | Crystalline Powder, Grains, Lumps or Flakes |
| color | Brown |
| PH | 9.6 (100g/l, H2O, 20℃) |
| Water Solubility | 100 g/L (20 ºC) |
| Merck | 14,479 |
| BRN | 105738 |
| CAS DataBase Reference | 96-50-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Aminothiazole(96-50-4) |
| EPA Substance Registry System | 2-Aminothiazole (96-50-4) |
Safety information for 2-Aminothiazole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for 2-Aminothiazole
| InChIKey | RAIPHJJURHTUIC-UHFFFAOYSA-N |
2-Aminothiazole manufacturer
ALS INDIA LIFE SCIENCES
Madin Life Sciences Pvt Ltd
Retrosynth Finechem Pvt Ltd
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