2-Amino-2-phenylacetic acid
Synonym(s):(±)-α-Aminophenylacetic acid;DL -α-Phenylglycine
- CAS NO.:2835-06-5
- Empirical Formula: C8H9NO2
- Molecular Weight: 151.17
- MDL number: MFCD00064402
- EINECS: 220-608-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 13:17:44
What is 2-Amino-2-phenylacetic acid?
Description
2-Amino-2-phenylacetic acid is a natural compound that has been identified as a selective inhibitor of cyclooxygenase 2 (COX-2), and it exhibits antiinflammatory activity. It has been shown to inhibit COX-2 at low concentrations and to be less potent than aspirin in inhibiting COX-1. It is also an amide, with a molecular weight of 296. In order to determine the structure of it, XRD data was collected from the monosodium salt form of the compound. The ester hydrochloride form was used for enzyme activity assays because it is more soluble in water than the free base form. The synthesis of 2-Amino-2-phenylacetic acid was achieved through a two step process involving amide formation and hydrolysis.
Chemical properties
white amorphous powder
The Uses of 2-Amino-2-phenylacetic acid
DL-α-Phenylglycine is used as a reagent in the synthesis of benzoquinone-amino acid conjugates which have antibacterial activity.
Definition
ChEBI: An amino acid with a structure in which a phenyl ring is bonded to the alpha-carbon of glycine.
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 3, p. 84, 1955
Synthetic Communications, 2, p. 423, 1972 DOI: 10.1080/00397917208081791
Properties of 2-Amino-2-phenylacetic acid
Melting point: | 290 °C (subl.)(lit.) |
Boiling point: | 273.17°C (rough estimate) |
alpha | [α]D20-0.5~+0.5゜ (c=5, dil. HCl) |
Density | 1.2023 (rough estimate) |
refractive index | 1.5810 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | almost transparency in Sodium hydroxide solution |
form | Crystalline Powder |
pka | 1.94±0.10(Predicted) |
color | White to off-white |
Water Solubility | 115g/L(100 ºC) |
Merck | 14,7291 |
BRN | 3197862 |
CAS DataBase Reference | 2835-06-5(CAS DataBase Reference) |
NIST Chemistry Reference | Benzeneacetic acid, «alpha»-amino-, (.+/-.)-(2835-06-5) |
EPA Substance Registry System | 2-Phenylglycine (2835-06-5) |
Safety information for 2-Amino-2-phenylacetic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Amino-2-phenylacetic acid
InChIKey | ZGUNAGUHMKGQNY-UHFFFAOYSA-N |
Abamectin manufacturer
JSK Chemicals
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