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HomeProduct name list2-Amino-2-phenylacetic acid

2-Amino-2-phenylacetic acid

Synonym(s):(±)-α-Aminophenylacetic acid;DL-α-Phenylglycine

  • CAS NO.:2835-06-5
  • Empirical Formula: C8H9NO2
  • Molecular Weight: 151.17
  • MDL number: MFCD00064402
  • EINECS: 220-608-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 11:41:24
2-Amino-2-phenylacetic acid Structural

What is 2-Amino-2-phenylacetic acid?

Description

2-Amino-2-phenylacetic acid is a natural compound that has been identified as a selective inhibitor of cyclooxygenase 2 (COX-2), and it exhibits antiinflammatory activity. It has been shown to inhibit COX-2 at low concentrations and to be less potent than aspirin in inhibiting COX-1. It is also an amide, with a molecular weight of 296. In order to determine the structure of it, XRD data was collected from the monosodium salt form of the compound. The ester hydrochloride form was used for enzyme activity assays because it is more soluble in water than the free base form. The synthesis of 2-Amino-2-phenylacetic acid was achieved through a two step process involving amide formation and hydrolysis.

Chemical properties

white amorphous powder

The Uses of 2-Amino-2-phenylacetic acid

DL-α-Phenylglycine is used as a reagent in the synthesis of benzoquinone-amino acid conjugates which have antibacterial activity.

Definition

ChEBI: An amino acid with a structure in which a phenyl ring is bonded to the alpha-carbon of glycine.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 84, 1955
Synthetic Communications, 2, p. 423, 1972 DOI: 10.1080/00397917208081791

Properties of 2-Amino-2-phenylacetic acid

Melting point: 290 °C (subl.)(lit.)
Boiling point: 273.17°C (rough estimate)
alpha  [α]D20-0.5~+0.5゜ (c=5, dil. HCl)
Density  1.2023 (rough estimate)
refractive index  1.5810 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  almost transparency in Sodium hydroxide solution
form  Crystalline Powder
pka 1.94±0.10(Predicted)
color  White to off-white
Water Solubility  115g/L(100 ºC)
Merck  14,7291
BRN  3197862
CAS DataBase Reference 2835-06-5(CAS DataBase Reference)
NIST Chemistry Reference Benzeneacetic acid, «alpha»-amino-, (.+/-.)-(2835-06-5)
EPA Substance Registry System 2-Phenylglycine (2835-06-5)

Safety information for 2-Amino-2-phenylacetic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Amino-2-phenylacetic acid

InChIKey ZGUNAGUHMKGQNY-UHFFFAOYSA-N

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