2-Adamantanamine hydrochloride

Synonym(s):2-Adamantanamine hydrochloride;2-Aminoadamantane hydrochloride

CAS NO.：10523-68-9
Empirical Formula: C10H18ClN
Molecular Weight: 187.71
MDL number: MFCD00074743
EINECS: 234-074-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-04 16:04:00

2-Adamantanamine hydrochloride Structural

What is 2-Adamantanamine hydrochloride?

Chemical properties

white crystalline powder

The Uses of 2-Adamantanamine hydrochloride

2-Adamantanamine Hydrochloride can be used to prepare CD73 inhibitors to treat CD73-associated diseases, including cancer and immune-related disorders.

The Uses of 2-Adamantanamine hydrochloride

2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2?-(carboxymethoxime)-olivomycin I. The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

General Description

The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied.

Purification Methods

The free amine in Et2O, liberated by the action of alkali in H2O, is dried over KOH, filtered, evaporated and sublimed at 110o/12torr, m 230-236o. The base is dissolved in EtOH, sufficient ethanolic HCl is added dropwise and crystallised by the addition of Et2O. Dry it in vacuo. [Stetter et al. Justus Liebigs Ann Chem 658 151 1962].

Properties of 2-Adamantanamine hydrochloride

Melting point:	>300 °C(lit.)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Crystalline Powder
color	White
Water Solubility	soluble
BRN	4297901
InChI	InChI=1/C10H17N.ClH/c11-10-8-2-6-1-7(4-8)5-9(10)3-6;/h6-10H,1-5,11H2;1H/t6-,7+,8-,9+,10?;
CAS DataBase Reference	10523-68-9(CAS DataBase Reference)

Safety information for 2-Adamantanamine hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.