2-Acetyl-1-methylpyrrole

CAS NO.：932-16-1
Empirical Formula: C7H9NO
Molecular Weight: 123.15
MDL number: MFCD00003089
EINECS: 213-247-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-24 19:19:26

What is 2-Acetyl-1-methylpyrrole?

Description

May be prepared from Af-methyl pyrrole and Grignard reagent; by acetylation of 1-methyl-pyrrole.

Chemical properties

CLEAR COLOURLESS TO LIGHT BROWN LIQUID

Occurrence

Reported found as a component in coffee aroma, asparagus, crispbread, cooked beef, black tea, okra and clam.

The Uses of 2-Acetyl-1-methylpyrrole

2-Acetyl-1-methylpyrrole was employed as model pyrrole to investigate the antioxidative activity of nonenzymatic browning reactions. It was employed as catalyst for the sulfonylation of spectinomycin.

Definition

ChEBI: A pyrrole carrying methyl and acetyl substituent at the 1- and 2-positions respectively.

Preparation

From N-methyl pyrrole and Grignard reagent; by acetylation of 1-methyl-pyrrole.

Aroma threshold values

Detection: 100 ppb

Synthesis Reference(s)

Synthetic Communications, 21, p. 557, 1991 DOI: 10.1080/00397919108016783

General Description

Reduction of 2-acetyl-1-methylpyrrole with sodium borohydride has been investigated.

Properties of 2-Acetyl-1-methylpyrrole

Boiling point:	200-202 °C (lit.)
Density	1.04 g/mL at 25 °C (lit.)
refractive index	n20/D 1.542(lit.)
FEMA	3184 \| 1-METHYL-2-ACETYLPYRROLE
Flash point:	155 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
pka	-7.46±0.70(Predicted)
Specific Gravity	1.040
color	Colorless to Yellow to Orange
Odor	at 100.00 %. earthy
JECFA Number	1306
BRN	111887
CAS DataBase Reference	932-16-1(CAS DataBase Reference)
NIST Chemistry Reference	Ethanone, 1-(1-methyl-1H-pyrrol-2-yl)-(932-16-1)
EPA Substance Registry System	2-Acetyl-1-methylpyrrole (932-16-1)

Safety information for 2-Acetyl-1-methylpyrrole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..…