2-(4-Chlorophenoxy)-2-methylpropionic acid
Synonym(s):α-(p-Chlorophenoxy)isobutyric acid;2-(p-Chlorophenoxy)-2-methylpropionic acid;Clofibric acid
- CAS NO.：882-09-7
- Empirical Formula: C10H11ClO3
- Molecular Weight: 214.65
- MDL number: MFCD00004192
- EINECS: 212-925-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is 2-(4-Chlorophenoxy)-2-methylpropionic acid?
Description
Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 μM in a transactivation assay) and the active metabolite of clofibrate . It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 μg/L. Clofibric acid has been found in wastewater effluent.
Chemical properties
Pale Yellow Solid
The Uses of 2-(4-Chlorophenoxy)-2-methylpropionic acid
Antilipemic.
The Uses of 2-(4-Chlorophenoxy)-2-methylpropionic acid
herbicide, antihyperlipoproteinemic, antineoplastic
The Uses of 2-(4-Chlorophenoxy)-2-methylpropionic acid
A hypolipidemic compound
What are the applications of Application
Clofibric acid is a hypolipidemic compound
Definition
ChEBI: A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Biological Activity
PPAR agonist. Antihyperlipoproteinemic.
Properties of 2-(4-Chlorophenoxy)-2-methylpropionic acid
| Melting point: | 120-122 °C(lit.) |
| Boiling point: | 308.11°C (rough estimate) |
| Density | 1.2413 (rough estimate) |
| refractive index | 1.5220 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| form | Crystals or Crystalline Powder |
| pka | 3.18±0.10(Predicted) |
| color | Pale yellow to brownish |
| Merck | 14,2378 |
| BRN | 1874067 |
| CAS DataBase Reference | 882-09-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Clofibric acid(882-09-7) |
| EPA Substance Registry System | Propanoic acid, 2-(4-chlorophenoxy)-2-methyl- (882-09-7) |
Safety information for 2-(4-Chlorophenoxy)-2-methylpropionic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-(4-Chlorophenoxy)-2-methylpropionic acid
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