2-(4-Chlorophenoxy)-2-methylpropionic acid

Synonym(s):α-(p-Chlorophenoxy)isobutyric acid;2-(p-Chlorophenoxy)-2-methylpropionic acid;Clofibric acid

CAS NO.：882-09-7
Empirical Formula: C10H11ClO3
Molecular Weight: 214.65
MDL number: MFCD00004192
EINECS: 212-925-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 19:38:33

2-(4-Chlorophenoxy)-2-methylpropionic acid Structural

What is 2-(4-Chlorophenoxy)-2-methylpropionic acid?

Description

Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC₅₀ = 50 μM in a transactivation assay) and the active metabolite of clofibrate . It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 μg/L. Clofibric acid has been found in wastewater effluent.

Chemical properties

Pale Yellow Solid

The Uses of 2-(4-Chlorophenoxy)-2-methylpropionic acid

Antilipemic.

The Uses of 2-(4-Chlorophenoxy)-2-methylpropionic acid

herbicide, antihyperlipoproteinemic, antineoplastic

The Uses of 2-(4-Chlorophenoxy)-2-methylpropionic acid

A hypolipidemic compound

What are the applications of Application

Clofibric acid is a hypolipidemic compound

Definition

ChEBI: A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.

Biological Activity

PPAR agonist. Antihyperlipoproteinemic.

Properties of 2-(4-Chlorophenoxy)-2-methylpropionic acid

Melting point:	120-122 °C(lit.)
Boiling point:	308.11°C (rough estimate)
Density	1.2413 (rough estimate)
refractive index	1.5220 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Methanol
form	Crystals or Crystalline Powder
pka	3.18±0.10(Predicted)
color	Pale yellow to brownish
Merck	14,2378
BRN	1874067
CAS DataBase Reference	882-09-7(CAS DataBase Reference)
NIST Chemistry Reference	Clofibric acid(882-09-7)
EPA Substance Registry System	Propanoic acid, 2-(4-chlorophenoxy)-2-methyl- (882-09-7)

Safety information for 2-(4-Chlorophenoxy)-2-methylpropionic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..…